3-(5-methylpyrid-2-yl)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(5-methylpyrid-2-yl)quinoline
• 英文别名: 3-(5-Methyl-pyridin-2-yl)-quinoline；3-(5-methylpyridin-2-yl)quinoline
• 化学式: C₁₅H₁₂N₂
• 分子量: 220.274
• InChiKey: SBKOOCRHLWHFOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N-dimethyl-2-(5-methylpyridin-2-yl)ethen-1-amine 、 N-苯基甲酰胺 在 三氯氧磷 作用下， 以 氯仿 为溶剂， 反应 2.5h， 以32%的产率得到3-(5-methylpyrid-2-yl)quinoline
  参考文献：
  名称：

  Investigations in 2,3′-biquinoline series 24. Synthesis of 3-hetarylquinolines and their 1,4-dihydro derivatives under conditions of the Vilsmeier reaction

  摘要：

  Methods have been developed for the synthesis of 2,3'-biquinolines, their 1',4'-dihydro derivatives, 3-pyrid-2-ylquinolines, and 3-pyrazin-2-ylquinoline based on the interaction of hetarylethylenes and vinyl butyl ether with imidoyl chlorides and Vilsmeier complexes. Using the example of the synthesis of 3-hetarylquinolines and their dihydro derivatives the synthetic possibilities of the Vilsmeier method were shown for creating various bonds in different quinoline nuclei of the bisheterocyclic system.

  DOI：

  10.1007/s10593-008-0138-x

文献信息

• 1,3,5-TRIAZINE DERIVATIVE, PROCESS FOR PRODUCING SAME, AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME AS CONSTITUENT COMPONENT
  申请人：Aihara Hidenori

  公开号：US20110190494A1

  公开（公告）日：2011-08-04

  A 1,3,5-triazine derivative represented by the formula (1): wherein R 1 , R 2 and R 3 each independently represent a hydrogen atom or a methyl group; X represents a carbon atom or a nitrogen atom; Ar 1 represents a substituted or unsubstituted aromatic hydrocarbon group; Ar 2 represents an C 1-4 alkyl-substituted or unsubstituted aromatic 6-membered heterocyclic group having one or two nitrogen atoms, which may be a condensed ring compound. An organic electroluminescent device comprising the 1,3,5-triazine derivative exhibits low power consumption and long lifetime.

  一种由式（1）表示的1,3,5-三嗪衍生物： 其中R1、R2和R3各自独立地表示氢原子或甲基基团；X表示碳原子或氮原子；Ar1表示取代或未取代的芳香烃基团；Ar2表示具有一个或两个氮原子的取代或未取代的芳香族6元杂环基团，可以是一个缩合环化合物。含有1,3,5-三嗪衍生物的有机电致发光器件具有低功耗和长寿命。
• Straightforward access to methyl-polyheterocycles from direct para-lithiation of 3-picoline
  作者：Julien Mathieu、Philippe Gros、Yves Fort

  DOI：10.1016/s0040-4039(01)00033-8

  日期：2001.3

  Various heterocycles have been introduced on the 3-picoline nucleus via a regioselective BuLi-Me2N(CH2)(2)OLi (BuLi-LiDMAE) mediated para-lithiation. Useful methyl-polyheterocycles were efficiently prepared by a one-pot lithiation-stannylation-Stille coupling sequence. (C) 2001 Published by Elsevier Science Ltd.
• US8735577B2
  申请人：——

  公开号：US8735577B2

  公开（公告）日：2014-05-27
• [EN] CARBAZOLE COMPOUND HAVING SUBSTITUENT GROUP INCLUDING ELECTRON-ACCEPTING NITROGEN-CONTAINING HETEROARYL, AND ORGANIC ELECTROLUMINESCENT ELEMENT<br/>[FR] COMPOSÉ DE CARBAZOLE PRÉSENTANT UN GROUPE SUBSTITUANT COMPRENANT UN HÉTÉROARYLE ACCEPTANT LES ÉLECTRONS CONTENANT DE L'AZOTE ET ÉLÉMENT ORGANIQUE ÉLECTROLUMINESCENT
  申请人：JNC CORP

  公开号：WO2011152466A1

  公开（公告）日：2011-12-08

  発光素子の寿命および駆動電圧が優れた有機電界発光素子を提供することを目的とする。 下記式（１－１）で表されるカルバゾール化合物を、電子輸送材料として用いて、有機電界発光素子を製造する。 （上記式（１－１）中、Ｒはアリール又はヘテロアリールであり、Ｈｙ１およびＨｙ２は、それぞれ独立して、炭素数２～２４の電子受容性窒素含有ヘテロアリールであり、Ａｒ１およびＡｒ２は、それぞれ独立して、炭素数６～２４のアリーレンである。）
• Investigations in 2,3′-biquinoline series 24. Synthesis of 3-hetarylquinolines and their 1,4-dihydro derivatives under conditions of the Vilsmeier reaction
  作者：T. P. Glushenko、V. I. Goncharov、A. V. Aksenov

  DOI：10.1007/s10593-008-0138-x

  日期：2008.8

  Methods have been developed for the synthesis of 2,3'-biquinolines, their 1',4'-dihydro derivatives, 3-pyrid-2-ylquinolines, and 3-pyrazin-2-ylquinoline based on the interaction of hetarylethylenes and vinyl butyl ether with imidoyl chlorides and Vilsmeier complexes. Using the example of the synthesis of 3-hetarylquinolines and their dihydro derivatives the synthetic possibilities of the Vilsmeier method were shown for creating various bonds in different quinoline nuclei of the bisheterocyclic system.