1-bromo-2-(1-hydroxy-2,2,2-trifluoroethyl)naphthalene

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-bromo-2-(1-hydroxy-2,2,2-trifluoroethyl)naphthalene
• 英文别名: 1-(1-Bromonaphthalen-2-yl)-2,2,2-trifluoroethanol；1-(1-bromonaphthalen-2-yl)-2,2,2-trifluoroethanol
• 化学式: C₁₂H₈BrF₃O
• 分子量: 305.094
• InChiKey: NKLMCEXMJQLSLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三氟甲烷 、 1-溴-2-萘甲醛 在 1-叔丁基-4,4,4-三(二甲氨基)-2,2-二[三(二甲氨基)-正膦亚基氨基]-2Λ5,4Λ5-连二(磷氮基化合物) 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 3.0h， 以65%的产率得到1-bromo-2-(1-hydroxy-2,2,2-trifluoroethyl)naphthalene
  参考文献：
  名称：

  Organocatalysis approach to trifluoromethylation with fluoroform

  摘要：

  The organic base methodology exploits an access to generate the "trifluoromethyl anion" for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P-4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation products were obtained efficiently. (C) 2013 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2013.07.018

文献信息

• Organocatalysis approach to trifluoromethylation with fluoroform
  作者：Yuan Zhang、Motohiro Fujiu、Hiroki Serizawa、Koichi Mikami

  DOI：10.1016/j.jfluchem.2013.07.018

  日期：2013.12

  The organic base methodology exploits an access to generate the "trifluoromethyl anion" for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P-4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation products were obtained efficiently. (C) 2013 Published by Elsevier B.V.