DL-(4S,5S)-1-benzyl-4-(4-methoxyphenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazole-4-carboxylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: DL-(4S,5S)-1-benzyl-4-(4-methoxyphenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazole-4-carboxylic acid
• 英文别名: (4S,5S)-3-benzyl-5-(4-methoxyphenyl)-2,4-diphenyl-4H-imidazole-5-carboxylic acid
• 化学式: C₃₀H₂₆N₂O₃
• 分子量: 462.548
• InChiKey: QNJHCXKKPDFFAI-FIBWVYCGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  DL-(4S,5S)-1-benzyl-4-(4-methoxyphenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazole-4-carboxylic acid 在 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 为溶剂， 反应 26.0h， 生成 DL-(4R,5S)-(1-benzyl-4-(4-methoxyphenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazol-4-yl)(phenyl)methanone
  参考文献：
  名称：

  Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis-imidazolines

  摘要：

  An efficient synthetic methodology of converting trans-4,5-diaryl-2-imidazolines to the corresponding cis-4,5-diaryl-2-imidazolines has been developed. This methodology features mild reaction conditions and a simple one-pot two-step procedure. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.022
• 作为产物：
  描述：

  苯甲醛 在 三甲基氯硅烷 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 24.0h， 生成 DL-(4S,5S)-1-benzyl-4-(4-methoxyphenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazole-4-carboxylic acid
  参考文献：
  名称：

  Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis-imidazolines

  摘要：

  An efficient synthetic methodology of converting trans-4,5-diaryl-2-imidazolines to the corresponding cis-4,5-diaryl-2-imidazolines has been developed. This methodology features mild reaction conditions and a simple one-pot two-step procedure. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.022

文献信息

• Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis-imidazolines
  作者：Ke Qu、Jason S. Fisk、Jetze J. Tepe

  DOI：10.1016/j.tetlet.2011.07.022

  日期：2011.9

  An efficient synthetic methodology of converting trans-4,5-diaryl-2-imidazolines to the corresponding cis-4,5-diaryl-2-imidazolines has been developed. This methodology features mild reaction conditions and a simple one-pot two-step procedure. (C) 2011 Elsevier Ltd. All rights reserved.