6-methyl-2-pentyl-3-(prop-1-en-2-yl)tetrahydro-2H-pyran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 6-methyl-2-pentyl-3-(prop-1-en-2-yl)tetrahydro-2H-pyran
• 英文别名: (2S,3S,6R)-6-methyl-2-pentyl-3-prop-1-en-2-yloxane
• 化学式: C₁₄H₂₆O
• 分子量: 210.36
• InChiKey: LQIPNJCPADAKNN-RDBSUJKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-甲基-5-庚烯-2-醇 、 正己醛 在 碘 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以90%的产率得到6-methyl-2-pentyl-3-(prop-1-en-2-yl)tetrahydro-2H-pyran
  参考文献：
  名称：

  A simple and expeditious synthesis of 2,3,6-trisubstituted tetrahydropyrans through (3,5)-oxonium-ene cyclization using molecular iodine

  摘要：

  A variety of aldehydes undergo a smooth coupling with 6-methylhept-5-en-2ol in the presence of molecular iodine to afford the 2,3,6-trisubstituted tetrahydropyrans in good yields through 3,5-oxonium-ene cyclization under mild and neutral conditions. This method is simple, convenient, and cost-effective. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.104

文献信息

• A simple and expeditious synthesis of 2,3,6-trisubstituted tetrahydropyrans through (3,5)-oxonium-ene cyclization using molecular iodine
  作者：N. Prudhvi Raju、B. Jagan Mohan Reddy、R. Anjibabu、K. Muralikrishna、B.V. Subba Reddy

  DOI：10.1016/j.tetlet.2013.04.104

  日期：2013.7

  A variety of aldehydes undergo a smooth coupling with 6-methylhept-5-en-2ol in the presence of molecular iodine to afford the 2,3,6-trisubstituted tetrahydropyrans in good yields through 3,5-oxonium-ene cyclization under mild and neutral conditions. This method is simple, convenient, and cost-effective. (C) 2013 Elsevier Ltd. All rights reserved.