优心平

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 优心平
• 英文名称: hydron;3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate;dichloride
• 化学式: C30H46Cl2N2O10
• 分子量: 665.6
• InChiKey: GIOKUMNZQFCEPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.24
• 重原子数：
  44
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Implantable medical device coated with a bioactive agent
  申请人：Ruane H. Patrick

  公开号：US20070207184A1

  公开（公告）日：2007-09-06

  The present invention provides an implantable medical device comprising a bioactive agent and poly(alkyl cyanoacrylate) polymer. In one embodiment of the invention, the bioactive agent is a water-soluble material, such as an antisense agent.
• METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP
  申请人：Abraham Soman N.

  公开号：US20110171195A1

  公开（公告）日：2011-07-14

  Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof. In particular, the compositions and kits may also include at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs.
• US4902516A
  申请人：——

  公开号：US4902516A

  公开（公告）日：1990-02-20
• US8092819B2
  申请人：——

  公开号：US8092819B2

  公开（公告）日：2012-01-10
• [EN] METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DES INFECTIONS DE L'APPAREIL URINAIRE EN UTILISANT DES AGENTS QUI IMITENT OU AUGMENTENT L'AMP CYCLIQUE
  申请人：UNIV DUKE

  公开号：WO2008157205A2

  公开（公告）日：2008-12-24

  [EN] Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof. In particular, the compositions and kits may also include at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs.
  [FR] L'invention concerne des procédés et des compositions destinés au traitement d'une infection de l'appareil urinaire (UTI). Les procédés impliquent l'administration à un sujet qui en a besoin d'un élévateur de cAMP ou d'un agent qui imite cAMP, en particulier un diterpène de labdane tel qu'une forskoline ou un dérivé ou une substance analogue à celle-ci en une quantité thérapeutiquement efficace pour traiter une UTI. Les procédés peuvent comprendre en outre l'administration d'au moins un élévateur de cAMP en combinaison avec un ou plusieurs composés actifs supplémentaires provenant d'autres classes d'agents thérapeutiques, tels que des agents antimicrobiens ou des médicaments pour abaisser le cholestérol. Les compositions de l'invention comprennent des compositions pharmaceutiques et des kits pour traiter une UTI chez un sujet le nécessitant, qui comprennent des quantités thérapeutiquement efficaces d'au moins deux élévateurs de cAMP, en particulier quand l'un des élévateurs de cAMP est un diterpène de labdane tel qu'une forskoline ou un dérivé ou une substance similaire à celle-ci. En particulier, les compositions et les kits peuvent aussi comprendre au moins un élévateur de cAMP en combinaison avec un ou plusieurs composés actifs additionnels provenant d'autres classes d'agents thérapeutiques, tels que des agents antimicrobiens ou des médicaments pour abaisser le cholestérol.