SQ-775

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂卓
• 英文名称: SQ-775
• 英文别名: N,N'-bis(2-adamantane)homopiperazine；1,4-Bis(2-adamantyl)-1,4-diazepane
• 化学式: C₂₅H₄₀N₂
• 分子量: 368.606
• InChiKey: USLMSRRGTCBRDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  9.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  高哌嗪 、 金刚烷酮 在 polymer-bound trimethylammonium cyanoborohydride 作用下， 以 溶剂黄146 、 1,2-二氯乙烷 为溶剂， 以41%的产率得到SQ-775
  参考文献：
  名称：

  Identification of New Diamine Scaffolds with Activity against Mycobacterium tuberculosis

  摘要：

  A diverse 5000-compound library was synthesized from commercially available diamines and screened for activity against Mycobacterium tuberculosis in vitro, revealing 143 hits with minimum inhibitory concentration (MIC) equal to or less than 12.5 mu M. New prospective scaffolds with antitubercular activity derived from homopiperazine, phenyl- and benzyl-substituted piperazines, 4-aminomethylpiperidine, 4-aminophenylethylamine, and 4,4'-methylenebiscyclohexylamine were identified. Compound SQ775 derived from homopiperazine and compound SQ786 derived from benzylpiperazine had potent antimicrobial activity against M. tuberculosis in experimental animals in vivo.

  DOI：

  10.1021/jm050948+

文献信息

• Methods and compositions comprising diamines as new anti-tubercular therapeutics
  申请人：Bogatcheva Elena

  公开号：US20050113574A1

  公开（公告）日：2005-05-26

  Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising novel diamine compositions for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.

  治疗传染性病原体引起的疾病，特别是结核病的方法和组合物。特别是提供了包含新型二胺组合物的用于治疗传染性疾病的方法和组合物。在一个实施方案中，这些方法和组合物用于治疗分枝杆菌感染，包括但不限于结核病。
• US7884097B2
  申请人：——

  公开号：US7884097B2

  公开（公告）日：2011-02-08
• Identification of New Diamine Scaffolds with Activity against <i>Mycobacterium tuberculosis</i>
  作者：Elena Bogatcheva、Colleen Hanrahan、Boris Nikonenko、Rowena Samala、Ping Chen、Jacqueline Gearhart、Francis Barbosa、Leo Einck、Carol A. Nacy、Marina Protopopova

  DOI：10.1021/jm050948+

  日期：2006.6.1

  A diverse 5000-compound library was synthesized from commercially available diamines and screened for activity against Mycobacterium tuberculosis in vitro, revealing 143 hits with minimum inhibitory concentration (MIC) equal to or less than 12.5 mu M. New prospective scaffolds with antitubercular activity derived from homopiperazine, phenyl- and benzyl-substituted piperazines, 4-aminomethylpiperidine, 4-aminophenylethylamine, and 4,4'-methylenebiscyclohexylamine were identified. Compound SQ775 derived from homopiperazine and compound SQ786 derived from benzylpiperazine had potent antimicrobial activity against M. tuberculosis in experimental animals in vivo.