依托昔布杂质J | 646459-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 依托昔布杂质J
• 英文名称: 5-Chloro-3-[4-(ethanesulfonyl)phenyl]-6'-methyl-2,3'-bipyridine
• 英文别名: 5-chloro-3-(4-ethylsulfonylphenyl)-2-(6-methylpyridin-3-yl)pyridine
• CAS: 646459-45-2
• 化学式: C₁₉H₁₇ClN₂O₂S
• 分子量: 372.9
• InChiKey: YEHBBVXKTFWRJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] HYDROGELATORS COMPRISING D-AMINO ACIDS<br/>[FR] COMPOSÉS FORMANT DES HYDROGELS COMPRENANT DES ACIDES AMINÉS D
  申请人：UNIV BRANDEIS

  公开号：WO2014074789A1

  公开（公告）日：2014-05-15

  Described herein are compounds comprising an oligopeptide and a non-steroidal antiinflammatory agent. The compounds self-assemble into supramolecular hydrogels and can be used as topical treatments for inflammatory conditions, such as osteoarthritis. Also described herein are oligopeptides compounds made from D-amino acid residues that form supramolecular hydrogels. The compounds may be functionalized with active agents, such as anticancer therapeutic agents, antiinflammatory agents, or imaging agents, therefore providing new mechanisms for delivery of active agents.

  本文描述了包含寡肽和非甾体抗炎药物的化合物。这些化合物自组装成超分子水凝胶，可用作治疗炎症病症，如骨关节炎的局部治疗。本文还描述了由D-氨基酸残基制成的寡肽化合物，形成超分子水凝胶。这些化合物可以与活性剂（如抗癌治疗剂、抗炎药物或成像剂）功能化，从而提供了传递活性剂的新机制。
• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF ETORICOXIB AND POLYMORPHS THEREOF<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION D'ÉTORICOXIBE ET DE POLYMORPHES DE CELUI-CI
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2013105106A1

  公开（公告）日：2013-07-18

  The invention relates to an improved process for the preparation of etoricoxib and polymorphs thereof. In particular, the, invention relates to a process for the preparation of stable crystalline Form-I of etoricoxib. Further, the invention also relates to a process for the preparation of amorphous form of etoricoxib. The invention also relates to pharmaceutical compositions that include the stable crystalline Form-I of etoricoxib.

  该发明涉及一种改进的制备依托考昔布及其多晶型的方法。特别地，该发明涉及一种制备依托考昔布稳定结晶形式-I的方法。此外，该发明还涉及一种制备依托考昔布非晶态形式的方法。该发明还涉及包含依托考昔布稳定结晶形式-I的制药组合物。
• ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS
  申请人：Cannizzaro Carina

  公开号：US20090247488A1

  公开（公告）日：2009-10-01

  The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗炎化合物、含有这种化合物的组合物、包括给药这种化合物的治疗方法，以及用于制备这种化合物的有用过程和中间体。
• US7432261B2
  申请人：——

  公开号：US7432261B2

  公开（公告）日：2008-10-07
• [EN] VETERINARY METHOD AND COMPOSITION<br/>[FR] MÉTHODE ET COMPOSITION VÉTÉRINAIRES
  申请人：PFIZER LTD

  公开号：WO2007129169A2

  公开（公告）日：2007-11-15

  [EN] Inhibitors of COX-II are useful for improving reproductive success in female animals.
  [FR] L'invention concerne des inhibiteurs de COX-II utiles pour améliorer la réussite de reproduction chez des animaux femelles.