potassium 2,3,4,5-tetrafluorobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: potassium 2,3,4,5-tetrafluorobenzoate
• 英文别名: potassium;2,3,4,5-tetrafluorobenzoate
• 化学式: C₇HF₄O₂*K
• 分子量: 232.176
• InChiKey: DGTQADIZSHAYMV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.39
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  potassium 2,3,4,5-tetrafluorobenzoate 、 苯甲酰胺 在 silver(I) carbonate 、 copper(II) sulfate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 12.0h， 以38%的产率得到N-(2,3,4,5-tetrafluorophenyl)benzenamine
  参考文献：
  名称：

  CuSO4-mediated decarboxylative C–N cross-coupling of aromatic carboxylic acids with amides and anilines

  摘要：

  CuSO4-mediated decarboxylative C-N cross-coupling of aromatic carboxylic acid with amide has been developed, leading to N-arylamides in modest to excellent yields. Anilines bearing electron-withdrawing substituents could also couple efficiently with aromatic carboxylic acids to give diarylamines in good to excellent yields. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2014.12.085

文献信息

• Synthesis and characterization of novel fluoroterphenyls: self‐assembly of low‐molecular‐weight fluorescent organogel
  作者：Naif Ghazi Altoom

  DOI：10.1002/bio.4055

  日期：——

  Nucleophilic aromatic substitution has been highly para selective on a range of functionalized pentafluorobenzenes. Here, we demonstrate the utility of nucleophilic aromatic substitution chemistry for the preparation of fluorinated fluorescent low-molecular-weight organogels. The molecular design, synthesis and photophysical performance of a new class of thermoreversible and fluorescent low-molecular-weight

  亲核芳香取代对一系列功能化五氟苯具有高度对位选择性。在这里，我们展示了亲核芳香取代化学在制备氟化荧光低分子量有机凝胶中的效用。分子设计，合成和从一类新的热可逆的和荧光低分子量有机凝胶的光物理性能对位描述了烷氧基官能化的氟化三联苯。CuI催化的脱羧交叉偶联和亲核芳族取代化学均用于通过简单过滤从相应的氟苯甲酸钾盐和芳基碘以高产率和优异的纯度制备那些高度氟化的凝胶剂。制备了具有各种对端烷氧基尾部的各种氟化对称和不对称对三联苯。这些氟化三联苯使用 X 射线晶体学、差示扫描量热法、傅里叶变换红外光谱以及1 H、13 C 和19F 核磁共振。这些新材料的紫外可见光吸收和发射光谱分别显示出溶剂化变色和溶剂化氟变色行为。产生的氟化三联苯通过协同的π-π堆积和范德华相互作用发生自组装，导致各种有机溶剂凝胶化。扫描电子显微镜显示纤维状纳米结构的形成。探索了一些选定的氟化对称和不对称对三联苯的细胞毒性。
• Method for production of 2, 3, 4, 5-tetrafluorobenzoic acid
  申请人：Nippon Shokubai Kagaku Kogyo Co., Ltd

  公开号：EP0194671A2

  公开（公告）日：1986-09-17

  A method for the production of 2,3,4,5-tetrafluorobenzoic acid, which comprises effecting said production by decarbonating 3,4,5,6-tetrafluorophthalic acid in an aqueous medium adjusted to a pH in the range of 0.7 to 2.2 at a temperature in the range of 100° to 220°C.

  一种生产 2,3,4,5-四氟苯甲酸的方法，包括在水介质中对 3,4,5,6-四氟邻苯二甲酸进行脱碳，调节 pH 值范围为 0.7 至 2.2，温度范围为 100° 至 220°C。
• US4769492A
  申请人：——

  公开号：US4769492A

  公开（公告）日：1988-09-06
• CuSO4-mediated decarboxylative C–N cross-coupling of aromatic carboxylic acids with amides and anilines
  作者：Wei-Jian Sheng、Qing Ye、Wu-Bin Yu、Ren-Rong Liu、Meng Xu、Jian-Rong Gao、Yi-Xia Jia

  DOI：10.1016/j.tetlet.2014.12.085

  日期：2015.1

  CuSO4-mediated decarboxylative C-N cross-coupling of aromatic carboxylic acid with amide has been developed, leading to N-arylamides in modest to excellent yields. Anilines bearing electron-withdrawing substituents could also couple efficiently with aromatic carboxylic acids to give diarylamines in good to excellent yields. (C) 2014 Published by Elsevier Ltd.