3-thiazol-2-yl-isoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 3-thiazol-2-yl-isoquinoline
• 英文别名: 3-Thiazol-2-yl-isochinolin；2-Isoquinolin-3-yl-1,3-thiazole
• 化学式: C₁₂H₈N₂S
• 分子量: 212.275
• InChiKey: LUQOUWKMTMMPDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氰基异喹啉 在 乙醇 、 氨 作用下， 生成 3-thiazol-2-yl-isoquinoline
  参考文献：
  名称：

  ANALOGUES OF 2,2′-BIPYRIDYL WITH ISOQUINOLINE AND THIAZOLE RINGS. PART II

  摘要：

  在第一部分报告的工作的延续中，又制备了几种联吡啶类似物，并测定了铜和铁配合物的吸收光谱。结果与之前的化合物系列相同。

  DOI：

  10.1139/v54-084

文献信息

• THERAPEUTIC ANTIVIRAL PEPTIDES
  申请人：BUCKMAN BRAD

  公开号：US20100119479A1

  公开（公告）日：2010-05-13

  Disclosed herein are compounds represented by a formula: Therapeutic methods, compositions, medicaments, and dosage forms related thereto are also disclosed.

  本文披露了由以下公式表示的化合物：同时还披露了相关的治疗方法、组合物、药物和剂型。
• CYCLOMETALATED TRANSITION METAL COMPLEXES FOR MULTIPLEX ANALYTE DETECTION
  申请人：Berkelman Thomas R.

  公开号：US20100144046A1

  公开（公告）日：2010-06-10

  A complex containing a transition metal ion and a plurality of donor ligands each of which is fully coordinated to the transition metal ion and is either a nitrogen donor ligand or a cyclometalated donor ligand, such that at least one of the donor ligands is a cyclometalated donor ligand bears one or more reactive groups connected to at least one of the donor ligands through a linker that includes a chain of four or more atoms. The linker offers advantages that make the complex particularly effective in labeling biomolecules and in multiplex analyses.

  本文描述了一种包含过渡金属离子和多种供体配体的复合物，每个供体配体都与过渡金属离子完全配位，并且是氮供体配体或环金属供体配体，至少一个供体配体是带有一个或多个反应基团的环金属供体配体，该反应基团通过一个包含四个或更多原子的链连接到至少一个供体配体上。该链连接提供了优势，使得该复合物在标记生物分子和多重分析中特别有效。
• PHOTOLUMINESCENT METAL COMPLEXES FOR PROTEIN STAINING
  申请人：Bio-Rad Laboratories, Inc.

  公开号：EP2217608B1

  公开（公告）日：2012-09-05
• US8664396B2
  申请人：——

  公开号：US8664396B2

  公开（公告）日：2014-03-04
• [EN] PHOTOLUMINESCENT METAL COMPLEXES FOR PROTEIN STAINING<br/>[FR] COMPLEXES DE MÉTAUX PHOTOLUMINESCENTS POUR UNE COLORATION DE PROTÉINES
  申请人：BIO RAD LABORATORIES

  公开号：WO2009067603A1

  公开（公告）日：2009-05-28

  A method of staining a poly(amino acid) by contacting a poly(amino acid) with a complex of at least one of transition metal ion, and a plurality of donor ligands each of which is fully coordinated to the transition metal ion and is either a nitrogen donor ligand or a cyclometalated donor ligand, such that at least one of the donor ligands is a cyclometalated donor ligand. Donor ligands in a single complex can be the same or different. Nitrogen donor ligands will contain heteroaryl ring systems having from 10 to 40 ring atoms, where from 2 to 8 ring atoms are N, O, S, or combinations thereof, such that at least two ring atoms are N, wherein each nitrogen donor ligand is substituted with from 0 to 4 R1 groups. Cyclometalated donor ligands will likewise contain heteroaryl ring systems having from 10 to 40 ring atoms, where from 1 to 4 ring atoms are N, O, S or combinations thereof, such that at least one ring atom is N, wherein each Cyclometalated donor ligand is substituted with from 0 to 4 R1 groups. The R1 groups are C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, halogen, C1-6 haloalkyl, OR2, NR2R3, CN, C(O)R2, C(O)OR2, OC(O)R2, C(O)NR2R3, N(R2)C(O)R3, OC(O)NR2R3, N(R2)C(O)OR3, NR2C(O)NR3R4, NR2C(S)NR3R4, NO2, =O, aryl, heteroaryl, cycloalkyl or heterocycloalkyl. When two or more R1 groups are present on a single donor ligand, they can be the same or different. The R2, R3 and R4 groups are H or C1-12 alkyl. Each of the R2, R3 and R4 groups can be the same or different. Furthermore, the metal complex of the present invention is neutral or cationic in overall electronic charge, such that the metal complex is non covalently associated with the poly(amino acid). Thus, the metal complex stains the poly(amino acid).