(1Z)-2-oxo-N,2-diphenylethanehydrazonoyl bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1Z)-2-oxo-N,2-diphenylethanehydrazonoyl bromide
• 英文别名: (Z)-2-oxo-N,2-diphenylacetohydrazonoyl bromide；(Phenylhydrazono)bromomethyl phenyl ketone
• 化学式: C₁₄H₁₁BrN₂O
• 分子量: 303.158
• InChiKey: BYHFZXGIPKCNTE-VKAVYKQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1Z)-2-oxo-N,2-diphenylethanehydrazonoyl bromide 生成 (4-methylphenyl) (1E)-N-anilino-2-oxo-2-phenylethanimidothioate
  参考文献：
  名称：

  SHAWALI A. S.; ABDDELHAMID A. O., BULL. CHEM. SOC. JAP. , 1976, 49, NO 1, 321-324

  摘要：

  DOI：

文献信息

• Utilization of α-halocarbonyl compounds in the synthesis of thiazole, thiadiazole, and thiophene derivatives
  作者：Ehab Abdel-latif、Samir Bondock

  DOI：10.1002/hc.20206

  日期：2006.4

  toward a variety of several α-halo- carbonyl compounds was investigated. Thus, reaction of 1 with α-bromoketones, hydrazonoyl bromides, and 2-chloro-N-arylacetamides afforded the corresponding dihydrothiazole, 1,3,4-thiadiazole, and thiophene derivatives, respectively. The synthesis of thiazolidin-4-one 11, thiazolidin-5-one 12, and some azo derivatives of thiazolidin-5-one were described. 5-Arylazothiazoles

  研究了 2-苯基硫代氨基甲酰乙酸乙酯 1 对多种 α-卤代羰基化合物的行为。因此，1 与 α-溴酮、腙酰溴和 2-氯-N-芳基乙酰胺反应分别得到相应的二氢噻唑、1,3,4-噻二唑和噻吩衍生物。描述了 thiazolidin-4-one 11、thiazolidin-5-one 12 和 thiazolidin-5-one 的一些偶氮衍生物的合成。5-芳基偶氮噻唑 17 和 19 是通过腙酰溴 3 与不同硫脲衍生物的缩合反应合成的。© 2006 Wiley Periodicals, Inc. 杂原子化学 17:299–305, 2006; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.20206
• Synthesis and characterization of new pyrazole-based thiazoles
  作者：Abdou O. Abdelhamid、Sobhi M. Gomha

  DOI：10.1080/00397911.2017.1330961

  日期：2017.8.3

  ABSTRACT A series of new 5-(heteroaryldiazenyl)thiazole incorporating pyrazole moiety have been synthesized through coupling of the thiazole with the appropriate heteroaryldiazonium salts. The newly synthesized compounds were characterized by elemental analysis, spectroscopic (IR, 1H NMR, and Mass) data, and alternative synthesis whenever possible. GRAPHICAL ABSTRACT

  摘要 通过将噻唑与合适的杂芳基重氮盐偶联，合成了一系列新的含有吡唑部分的 5-(杂芳基二氮烯基)噻唑。新合成的化合物通过元素分析、光谱（IR、1H NMR 和质谱）数据以及可能的替代合成进行表征。图形概要
• Substituted Pyrazoles as Ghrelin Receptor Antagonists
  申请人：Ge Min

  公开号：US20090253673A1

  公开（公告）日：2009-10-08

  Certain novel N-acylated spiropiperidine derivatives are ligands of the human ghrelin receptor(s) and, in particular, are antagonists/inverse agonists of the human ghrelin receptor. They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of the ghrelin receptor, such as obesity, diabetes, and metabolic syndrome.

  某些新型N-酰化螺环哌啶衍生物是人类胃饥素受体的配体，特别是人类胃饥素受体的拮抗剂/逆向激动剂。因此，它们对于治疗、控制或预防对胃饥素受体调节敏感的疾病和疾病是有用的，如肥胖症、糖尿病和代谢综合征。
• Regioselective Synthesis of Novel 4,4′-and 5,5′-bi-(1,2,4-triazole) Derivatives
  作者：Ahmad M. Farag、Kamal M. Dawood、Nabila A. Khedr

  DOI：10.3184/030823407x237876

  日期：2007.8

  A regioselective synthesis is reported of a series of polysubstituted 1,2,4-triazoles and 4,4′- and 5,5′-bi-(1,2,4-triazoles) via 1,3-dipolar cycloaddition reactions of nitrilimines with some aza- and diaza-butadiene derivatives.

  报告了一系列多取代的 1,2,4-三唑以及 4,4′- 和 5,5′- 双（1,2,4-三唑）的区域选择性合成，这些合成是通过氮亚胺与一些氮杂和重氮丁二烯衍生物的 1,3-二极环加成反应实现的。
• Synthesis of 1,3,4-Thiadiazoles, α -Pyranone ,Pyridine, Polysubstituted Benzene from 1,3,4-Thiadiazolyl Ethanone and Testing Against Tuberculosis Based on Molecular Docking Studies
  作者：Mahmoud Abdelal

  DOI：10.13005/ojc/300321

  日期：2014.9.26

  The synthesis  is reported of new 1,3,4-thiadiazole, imidazopyridine, α-pyranone, pyrazolo[1,5-a]pyrimidine, polysubstituted benzene, pyridine , pyrazoles and pyrazolo[3,4-d]pyridazine using 1-(5Z)-5-[(4-methoxyphenyl)imino]-4-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl}ethanone as starting material.

  据报道，以1-(5Z)-5-[(4-甲氧基苯基)亚氨]-4-苯基-4,5-二氢-1,3,4-噻二唑-2-基}乙酮为起始原料，合成了一系列新型的1,3,4-噻二唑、咪唶并吡啶、α-吡喃酮、吡唑并[1,5-a]嘧啶、多取代苯、吡啶、吡唑以及吡唑并[3,4-d]吡嗪。