2,2'-(pyridine-2,6-diyl)bis[1H-isoindole-1,3(2H)-dione]

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2,2'-(pyridine-2,6-diyl)bis[1H-isoindole-1,3(2H)-dione]
• 英文别名: N,N'-pyridine-2,6-diyl-bis-phthalimide；N,N'-Pyridin-2,6-diyl-bis-phthalimid；2,6-Diphthalimidopyridine；2-[6-(1,3-dioxoisoindol-2-yl)pyridin-2-yl]isoindole-1,3-dione
• 化学式: C₂₁H₁₁N₃O₄
• 分子量: 369.336
• InChiKey: ILSYCXJRQWYBMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,6-二氨基吡啶 、 苯酐 在 without solvent 作用下， 生成 2,2'-(pyridine-2,6-diyl)bis[1H-isoindole-1,3(2H)-dione]
  参考文献：
  名称：

  Crippa; Long, Gazzetta Chimica Italiana, 1934, vol. 64, p. 83,89

  摘要：

  DOI：

文献信息

• Wanag; Veinbergs, Chemische Berichte, 1942, vol. 75, p. 1558,1567
  作者：Wanag、Veinbergs

  DOI：——

  日期：——
• Synthesis, characterization, DNA binding, antibacterial, and antioxidant activity of new bis-phthalimides
  作者：R. Arif、P. Sirajuddin Nayab、P. Rahisuddin

  DOI：10.1134/s1070363216060232

  日期：2016.6

  New bis-phthalimides were synthesized by 2: 1 condensation of phthalic anhydride and tetrachlorophthalic anhydride with 1,2,4-triazole-3,5-diamine, pyridine-2,6-diamine, and 4-hydroxypyrimidine- 2,6-diamine. The synthesized compounds were characterized by elemental analyses and IR, H-1 NMR, and mass spectra. Their interaction with calf thymus DNA (ct-DNA) was studied by UV-Vis spectrophotometry, cyclic voltammetry, and viscosity measurements, which revealed intercalative mode of binding to ct-DNA. Antibacterial activity of the synthesized compounds against Escherichia coli and Streptococcus mutans was assessed in vitro by the agar well diffusion method. The antioxidant activity of these compounds was estimated by DPPH assay.