2-chloro-N-(1-naphthylethyl)acetamide | 131149-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-chloro-N-(1-naphthylethyl)acetamide
• 英文别名: 2-chloro-N-[1-(1-naphthyl)ethyl]acetamide；PCM-0102275；2-chloro-N-(1-naphtylethyl)acetamide；2-chloro-N-[1-(naphthalen-1-yl)ethyl]acetamide；2-chloro-N-(1-naphthalen-1-ylethyl)acetamide
• CAS: 131149-67-2
• 化学式: C₁₄H₁₄ClNO
• mdl: MFCD08239614
• 分子量: 247.724
• InChiKey: FACKLPCSVDLOKS-UHFFFAOYSA-N

物化性质

• 沸点：
  458.3±38.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.214
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  轮环藤宁 、 2-chloro-N-(1-naphthylethyl)acetamide 在 三乙胺 作用下， 以 氯仿 为溶剂， 以100%的产率得到N-[1-(1-naphthyl)ethyl]-1,4,7,10-tetraazacyclododecane-1-acetamide
  参考文献：
  名称：

  Lanthanide-Functionalized Nanoparticles as MRI and Luminescent Probes for Sensing and/or Imaging Applications

  摘要：

  The combination of lanthanides and nanoparticles to develop new hybrid nanomaterials has become a highly topical area of research in the field of sensing, biomedical imaging, drug delivery, etc. However, these novel nanomaterials have to be carefully designed to ensure that the unique properties conveyed by each component, i.e., lanthanide ions and nanoparticles, are maximized and not negatively affected by one another. In this Forum Article, the main advances in the design of lanthanide-based nanoparticles will be discussed, with the first part focusing on the design of gadolinium(III)-based nanoparticles and their use as magnetic resonance imaging agents. The second part will then describe the main and most recent designs of luminescent lanthanide-based nanoparticles and their applications as sensors or imaging agents, with a special emphasis on our contribution to this area.

  DOI：

  10.1021/ic4023568
• 作为产物：
  描述：

  氯碘甲烷 、 1-(1-萘基)乙基异氰酸酯 在 甲基锂 、 lithium bromide 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以96%的产率得到2-chloro-N-(1-naphthylethyl)acetamide
  参考文献：
  名称：

  Homologation of Isocyanates with Lithium Carbenoids: A Straightforward Access to α-Halomethyl- and α,α-Dihalomethylamides

  摘要：

  Treatment of widely available isocyanates with monohalolithium and dihalolithium carbenoids provides a valuable protocol for the one-pot preparation of -halo- and ,-dihaloacetamide derivatives. While monohalolithium carbenoids can be prepared by a smooth lithium-halogen exchange, the preparation of the corresponding dihalo compounds proved to be highly dependent on the base used to realize the deprotonation, with lithium 2,2,6,6-tetramethylpiperidine emerging as optimal. The clear advantages of the procedure are: (a) broad scope of isocyanates that can be employed; (b) preservation of the optical purity when chiral materials are used; (c) divergent access to different haloamides by simply selecting the homologating agents. We also report an application of Charette's imidoyl triflate activation of a secondary amide to the synthesis of an -chloro ketone and N-15 NMR data for selected compounds.

  DOI：

  10.1055/s-0034-1379209

文献信息

• Substituted heterocyclic compounds
  申请人：——

  公开号：US20040152890A1

  公开（公告）日：2004-08-05

  Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

  本发明涉及新型杂环衍生物，可用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常、间歇性跛行、普林兹梅特尔（变异型）心绞痛、稳定和不稳定性心绞痛、运动诱发性心绞痛、充血性心力衰竭和心肌梗塞。该化合物也可用于糖尿病的治疗。
• FACILE CONVERSION OF ALCOHOLS INTO N-SUBSTITUTED AMIDES BY MAGNESIUM HYDROGENSULFATE UNDER HETEROGENEOUS CONDITIONS
  作者：P. Salehi、M. M. Khodaei、M. A. Zolfigol、A. Keyvan

  DOI：10.1081/scc-100104410

  日期：2001.1

  Different classes of alcohols react efficiently with nitriles in the presence of magnesium hydrogensulfate, Mg(HSO4)(2), to produce amides in high yields.
• Silica Gel Supported Ferric Perchlorate: A New and Efficient Reagent for One Pot Synthesis of Amides from Benzylic Alcohols
  作者：Peyman Salehi、Aghamorad Rostamian Motlagh

  DOI：10.1080/00397910008087369

  日期：2000.2

  Benzylic alcohols react efficiently with nitriles in the presence of silica gel supported ferric perchlorate to produce amides in high yields.
• ARMSTRONG, DANIEL W.;LI, WEIYONG;STALCUP, APRYLL M.;SECOR, HENRY V.;IZAC,+, ANAL. CHIM. ACTA , 234,(1990) N, C. 365-380
  作者：ARMSTRONG, DANIEL W.、LI, WEIYONG、STALCUP, APRYLL M.、SECOR, HENRY V.、IZAC,+

  DOI：——

  日期：——
• Substituted piperazine compounds and their use as fatty acid oxidation inhibitors
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1806346B1

  公开（公告）日：2009-07-22