N-(3-hydroxylpropyl)-cis-5-norbornene-exo-2,3-dicarboximide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(3-hydroxylpropyl)-cis-5-norbornene-exo-2,3-dicarboximide
• 英文别名: (1R,2R,6S,7S)-4-(3-hydroxypropyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.256
• InChiKey: LZZLQDMQTMMXCJ-FIRGSJFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-溴-2-甲基丙酰溴 、 N-(3-hydroxylpropyl)-cis-5-norbornene-exo-2,3-dicarboximide 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以72%的产率得到
  参考文献：
  名称：

  [EN] BIOACTIVE SYNTHETIC COPOLYMER, BIOACTIVE MACROMOLECULE AND RELATED METHODS THEREOF
  [FR] COPOLYMÈRE SYNTHÉTIQUE BIOACTIF, MACROMOLÉCULE BIOACTIVE ET PROCÉDÉS ASSOCIÉS

  摘要：

  There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.

  公开号：

  WO2022093106A1
• 作为产物：
  描述：

  3-氨基-1-丙醇 、 (1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione 以 二氯甲烷 为溶剂， 以85 %的产率得到N-(3-hydroxylpropyl)-cis-5-norbornene-exo-2,3-dicarboximide
  参考文献：
  名称：

  具有组合主链/侧链拓扑结构的异双金属嵌段共聚物

  摘要：

  我们首次报道了具有组合主链/侧链拓扑结构的异双金属嵌段共聚物的合成。这些聚合物的光物理、电化学和热性能以及开环复分解聚合诱导的结晶驱动自组装 (ROMPI-CDSA) 行为可以通过切换金属特性得到显着调节。

  DOI：

  10.1039/d2cc05990h

文献信息

• BOTTLEBRUSH COPOLYMERS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20180094099A1

  公开（公告）日：2018-04-05

  Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein.

  提供延长一个或多个治疗剂释放的材料（例如，颗粒、水凝胶）是药物传递的有用平台。在某种程度上，本发明涉及可用于制备颗粒和水凝胶以延长治疗剂释放的新三嵌段（ABC）瓶刷共聚物。在某些实施例中，本文描述的三嵌段瓶刷共聚物、颗粒和水凝胶对温度敏感，并在生理温度下凝胶（例如，在给予受试者后），提供可用于延长释放药物传递的可注射和/或可植入凝胶。本发明还提供了延长释放药物传递的方法，以及使用创新共聚物、颗粒和水凝胶治疗和/或预防受试者疾病或症状的方法。此外，本发明提供了制备本文描述的三嵌段瓶刷共聚物的方法。
• Synthesis, characterization, and thin-film properties of 6-oxoverdazyl polymers prepared by ring-opening metathesis polymerization
  作者：Joseph A. Paquette、Sabastine Ezugwu、Vishal Yadav、Giovanni Fanchini、Joe B. Gilroy

  DOI：10.1002/pola.28042

  日期：2016.6.15

  Redox‐active 6‐oxoverdazyl polymers were synthesized via ring‐opening metathesis polymerization (ROMP) and their solution, bulk, and thin‐film properties investigated. Detailed studies of the ROMP method employed confirmed that stable radical polymers with controlled molecular weights and narrow molecular weight distributions (Ð < 1.2) were produced. Thermal gravimetric analysis of a representative

  通过开环复分解聚合（ROMP）合成具有氧化还原活性的6-氧过二唑聚合物，并研究其溶液，体积和薄膜性能。对ROMP方法进行的详细研究证实，可以生产出具有受控分子量和窄分子量分布（Ð  <1.2）的稳定自由基聚合物。标题聚合物的代表性实例的热重分析表明，在高达190°C的条件下具有稳定性，而差示扫描量热法研究显示，其玻璃化转变温度为152°C。6-氧过二唑基单体12和聚合物13的光谱比较包括FT-IR，UV-vis吸收和电子顺磁共振波谱，用于定性和定量确定ROMP机理对6-氧过二氮基的耐受性。循环伏安法研究表明聚合物13的双极性氧化还原性质（ 相对于二茂铁/二茂铁，E 1/2，ox = 0.25和E 1/2，red = -1.35 V），与单体12一致。的聚合物薄膜的电荷传输性13之前和施加5伏的电位后进行了研究，揭示了从10中的电阻率的急剧下降6 -10 10 Ωm以上至1.7×104 Ωm
• [EN] HYALURONIC ACID-BASED SYNTHETIC COPOLYMER, MATERIAL CONTAINING SAID COPOLYMER AND RELATED METHODS THEREOF<br/>[FR] COPOLYMÈRE SYNTHÉTIQUE À BASE D'ACIDE HYALURONIQUE, MATÉRIAU CONTENANT LEDIT COPOLYMÈRE ET PROCÉDÉS ASSOCIÉS
  申请人：[en]AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：WO2023211384A1

  公开（公告）日：2023-11-02

  There is provided a regenerative material for skin, bone and/or cartilage tissue regeneration, the material comprising, a hyaluronic acid-based synthetic copolymer having one or more repeating units represented by general formula (Vlll-a). Also provided are a medical device comprising said regenerative material, medical uses of said regenerative material, hyaluronic acid-based macromolecule, and a method of preparing said hyaluronic acid-based macromolecule.
• Heterobimetallic block copolymers with a combined main-chain/side-chain topology
  作者：Ye Sha、Zhou Zhou、Jiale Zhang、Xiaofan Chen、Zhenyang Luo、Xiang Li

  DOI：10.1039/d2cc05990h

  日期：——

  We report for the first time the synthesis of heterobimetallic block copolymers with a combined main-chain/side-chain topology. The photophysical, electrochemical, and thermal properties and ring-opening metathesis polymerization-induced crystallization-driven self-assembly (ROMPI-CDSA) behavior of these polymers can be significantly modulated by switching the metal identity.

  我们首次报道了具有组合主链/侧链拓扑结构的异双金属嵌段共聚物的合成。这些聚合物的光物理、电化学和热性能以及开环复分解聚合诱导的结晶驱动自组装 (ROMPI-CDSA) 行为可以通过切换金属特性得到显着调节。
• [EN] BIOACTIVE SYNTHETIC COPOLYMER, BIOACTIVE MACROMOLECULE AND RELATED METHODS THEREOF<br/>[FR] COPOLYMÈRE SYNTHÉTIQUE BIOACTIF, MACROMOLÉCULE BIOACTIVE ET PROCÉDÉS ASSOCIÉS
  申请人：[en]AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：WO2022093106A1

  公开（公告）日：2022-05-05

  There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.