2-methyl-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-2-yl acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-methyl-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-2-yl acetate
• 英文别名: (2-Methyl-4-oxo-3,5,6,7-tetrahydro-1-benzofuran-2-yl) acetate；(2-methyl-4-oxo-3,5,6,7-tetrahydro-1-benzofuran-2-yl) acetate
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: FVBLUCZIKDCTDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methyl-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-2-yl acetate 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以95%的产率得到甲硫醇钠
  参考文献：
  名称：

  A new route for the synthesis of furanoflavone and furanochalcone natural products

  摘要：

  An efficient synthesis of furanoflavones and furanochalcones has been carried out starting from a dihydrobenzofuran derivative.

  DOI：

  10.1016/0040-4020(95)98689-f
• 作为产物：
  描述：

  乙酸异丙烯酯 、 2-diazocyclohexane-1,3-dione 在 rhodium(II) acetate dimer 作用下， 以 氟苯 为溶剂， 反应 10.0h， 以65%的产率得到2-methyl-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-2-yl acetate
  参考文献：
  名称：

  A new route for the synthesis of furanoflavone and furanochalcone natural products

  摘要：

  An efficient synthesis of furanoflavones and furanochalcones has been carried out starting from a dihydrobenzofuran derivative.

  DOI：

  10.1016/0040-4020(95)98689-f

文献信息

• Efficient One-Pot Synthesis of Multi-Substituted Dihydrofurans by Ruthenium(II)-Catalyzed [3+2] Cycloaddition of Cyclic or Acyclic Diazodicarbonyl Compounds with Olefins
  作者：Likai Xia、Yong Rok Lee

  DOI：10.1002/adsc.201300245

  日期：2013.8.12

  AbstractRuthenium(II)‐phosphine complexes‐catalyzed [3+2] cycloadditions were conducted to synthesize a variety of dihydrofurans by reactions of cyclic or acyclic diazodicarbonyl compounds with olefins. This method represents a direct and efficient one‐pot synthesis for multi‐substituted dihydrofurans under mild reaction conditions with an excellent regioselectivity. Furthermore, to reduce reaction times and increase yields of dihydrofurans, microwave‐assisted tris(triphenylphosphine)ruthenium(II) chloride/ 1‐butyl‐3‐methylimidazolium tetrafluoroborate Ru(PPh3)3Cl2/[Bmim]BF4}‐catalyzed reactions were also developed. The synthesized dihydrofurans can be readily converted into biologically interesting tetrahydroindoles.magnified image
• KR2016/20022
  申请人：——

  公开号：——

  公开（公告）日：——
• A new route for the synthesis of furanoflavone and furanochalcone natural products
  作者：Yong Rok Lee、Andrew T. Morehead

  DOI：10.1016/0040-4020(95)98689-f

  日期：1995.4

  An efficient synthesis of furanoflavones and furanochalcones has been carried out starting from a dihydrobenzofuran derivative.