trans-benzyl 2-benzylcyclopropanecarboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-benzyl 2-benzylcyclopropanecarboxylate
• 英文别名: benzyl (1R,2S)-2-benzylcyclopropane-1-carboxylate
• 化学式: C₁₈H₁₈O₂
• 分子量: 266.34
• InChiKey: CKWJQNNIAXELQF-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  烯丙苯 、 benzyl diazoacetate 在 copper plated iron nanoparticles (Cu&FeNPs) 作用下， 以 neat (no solvent) 为溶剂， 反应 12.0h， 以33.333%的产率得到
  参考文献：
  名称：

  Cyclopropanation of diazoesters with styrene derivatives catalyzed by magnetically recoverable copper-plated iron nanoparticles

  摘要：

  Simple bare copper-plated iron nanoparticles catalyzed the cyclopropanation of diazoesters with styrene derivatives. The reaction proceeded smoothly and provided the desired products in moderate to good yields, with selectivity for trans isomer in neat conditions. The reaction scope was explored and di or tri-substituted cyclopropanes were synthesized. The catalysts could be magnetically separated and reusable up to five times. It was also characterized by TEM, XPS, and ICP-MS. A gram-scale reaction was performed with a yield of 72%. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.09.011

文献信息

• Cyclopropanation of diazoesters with styrene derivatives catalyzed by magnetically recoverable copper-plated iron nanoparticles
  作者：Shingo Ishikawa、Reuben Hudson、Mitra Masnadi、Mary Bateman、Annie Castonguay、Nadi Braidy、Audrey Moores、Chao-Jun Li

  DOI：10.1016/j.tet.2014.09.011

  日期：2014.11

  Simple bare copper-plated iron nanoparticles catalyzed the cyclopropanation of diazoesters with styrene derivatives. The reaction proceeded smoothly and provided the desired products in moderate to good yields, with selectivity for trans isomer in neat conditions. The reaction scope was explored and di or tri-substituted cyclopropanes were synthesized. The catalysts could be magnetically separated and reusable up to five times. It was also characterized by TEM, XPS, and ICP-MS. A gram-scale reaction was performed with a yield of 72%. (C) 2014 Elsevier Ltd. All rights reserved.