2-(2-cyanopropyl) dithiobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-cyanopropyl) dithiobenzoate
• 英文别名: 2-(2-Cyanopropyl)benzenecarbodithioic acid；2-(2-cyanopropyl)benzenecarbodithioic acid
• 化学式: C₁₁H₁₁NS₂
• 分子量: 221.347
• InChiKey: FCNLLSFNCVSNOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  56.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] ANTIVIRAL CONJUGATES OF POLYANIONIC POLYMER AND ANTIVIRAL DRUG<br/>[FR] CONJUGUÉS ANTIVIRAUX DE POLYMÈRE POLYANIONIQUE ET MÉDICAMENT ANTIVIRAL
  申请人：UNIV AARHUS

  公开号：WO2016198072A1

  公开（公告）日：2016-12-15

  A compound is provided, which comprise an anionic polymer carrier conjugated to an antiviral drug via a biodegradable linker. This compound is particularly useful as a broad-spectrum antiviral agent.

  提供了一种化合物，其中包括通过可生物降解的连接剂与抗病毒药物结合的阴离子聚合物载体。这种化合物特别适用作为广谱抗病毒剂。
• [EN] POLYMER MATERIALS FOR DELIVERY OF SHORT-CHAIN FATTY ACIDS TO THE INTESTINE FOR APPLICATIONS IN HUMAN HEALTH AND TREATMENT OF DISEASE<br/>[FR] MATIÈRES POLYMÈRES POUR L'ADMINISTRATION D'ACIDES GRAS À CHAÎNE COURTE À L'INTESTIN POUR DES APPLICATIONS DE SANTÉ HUMAINE ET DE TRAITEMENT DE MALADIE
  申请人：UNIV CHICAGO

  公开号：WO2018195067A1

  公开（公告）日：2018-10-25

  Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.

  本文提供了一些聚合物材料，例如用于传递短链脂肪酸。具体来说，提供了形成稳定纳米级结构并释放其有效载荷的聚合物，例如通过共价键的断裂（例如通过水解或酶解）。这些聚合物可用于将有效载荷（例如SCFAs）传递到肠道，用于健康和治疗疾病的应用，并在与人类微生物群落变化相关的疾病中具有广泛适用性，包括炎症性、自身免疫、过敏、代谢和中枢神经系统疾病等。
• PEPTIDE-BASED VACCINES, METHODS OF MANUFACTURING, AND USES THEREOF FOR INDUCING AN IMMUNE RESPONSE
  申请人：Avidea Technologies, Inc.

  公开号：US20200054741A1

  公开（公告）日：2020-02-20

  The present disclosure relates to novel peptide-based vaccines, methods of manufacturing the novel peptide-based vaccines and uses thereof for delivering peptide antigens to induce an immune response, and in particular a T cell response to a subject.

  本公开涉及新型基于肽的疫苗，制造该新型基于肽的疫苗的方法以及将其用于传递肽抗原以诱导免疫应答，特别是T细胞应答给受试者。
• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• Polymerizable sulfonamide compounds and polymers thereof
  申请人：Massachusetts Institute of Technology

  公开号：US11155674B2

  公开（公告）日：2021-10-26

  Methods, compositions, reagents, and systems that allow for the preparation and utilization of sulfonamide salt polymer electrolytes are disclosed herein. Methods and reagents to prepare sulfonamide salt monomers are also disclosed herein. The sulfonamide salt polymer electrolytes can be used as components in energy storage devices, conductive materials, electrochemical cells, gels, adhesives, and drug delivery vehicles.

  本文公开了允许制备和利用磺胺盐聚合物电解质的方法、组合物、试剂和系统。本文还公开了制备磺胺盐单体的方法和试剂。磺胺盐聚合物电解质可用作能量存储设备、导电材料、电化学电池、凝胶、粘合剂和药物输送载体中的组件。