1-(methyl(phenyl)amino)butan-2-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(methyl(phenyl)amino)butan-2-ol
• 英文别名: 1-(N-methylanilino)butan-2-ol
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: SVYWKGGVSILLKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-苯基甲亚胺 在 sodium tetrahydroborate 、 cobalt(II) diacetate tetrahydrate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 4.0h， 生成 1-(methyl(phenyl)amino)butan-2-ol
  参考文献：
  名称：

  便捷的立体特异性共催化串联N-甲基苯胺与苯乙烯氧化物的C–N和C–O键†

  摘要：

  N-甲基苯胺与苯乙烯氧化物的钴（II）催化立体定向偶联是通过使用叔丁基氢过氧化物（TBHP）作为氧化剂，通过串联的C-N和C-O键形成的。光学活性的环氧化物可以高光学纯度反应。

  DOI：

  10.1039/c8cc06223d

文献信息

• Phenalenyl in a Different Role: Catalytic Activation through the Nonbonding Molecular Orbital
  作者：Sudipta Raha Roy、A. Nijamudheen、Anand Pariyar、Anup Ghosh、Pavan K. Vardhanapu、Prasun K. Mandal、Ayan Datta、Swadhin K. Mandal

  DOI：10.1021/cs5010695

  日期：2014.12.5

  We have demonstrated that the nonbonding molecular orbital (NBMO) of the phenalenyl (PLY) cation can be used as a Lewis acid catalyst for different organic transformations. Detailed computational and spectroscopic studies for the aminolysis reaction of epoxide reveal that this catalysis works through a different mechanism, and the phenalenyl cation activates the amine moiety using its empty NBMO, which triggers the epoxide ring-opening reaction. It has been shown that the energy of the NBMO of PLY cation plays a key role in modulating the catalytic activity. This study establishes that the cationic state of phenalenyl unit is useful not only for construction of the spin memory device by external spin injection using its NBMO, but in addition, the same NBMO can act as an organic Lewis acceptor unit to influence the catalytic outcome of a homogeneous reaction.
• Aluminium triflate: an efficient recyclable Lewis acid catalyst for the aminolysis of epoxides
  作者：D. Bradley G. Williams、Michelle Lawton

  DOI：10.1016/j.tetlet.2006.07.036

  日期：2006.9

  Epoxides are powerful starting materials for a range of useful materials and can be converted into, amongst others, amino alcohols. In this work, a range of epoxides was ring-opened using various alkyl- and arylamines under the action of aluminium triflate as a catalyst. This catalyst was found to be highly active, producing the desired amino alcohol products in high yields with low catalyst loadings. Additionally, it was shown that the aluminium triflate catalyst is recyclable by simple extraction into water and may be re-used several times. (c) 2006 Elsevier Ltd. All rights reserved.
• US3992349A
  申请人：——

  公开号：US3992349A

  公开（公告）日：1976-11-16
• US4024324A
  申请人：——

  公开号：US4024324A

  公开（公告）日：1977-05-17
• US4160643A
  申请人：——

  公开号：US4160643A

  公开（公告）日：1979-07-10