sodium trichloropyridinate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: sodium trichloropyridinate
• 英文别名: sodium;3,5,6-trichloropyridine-2-carboxylate
• 化学式: C₆HCl₃NO₂*Na
• 分子量: 248.428
• InChiKey: CSYKMPIRLUANIQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.59
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  sodium trichloropyridinate 生成 (3,5,6-三氯-2-吡啶基)氧基-乙酸乙酯
  参考文献：
  名称：

  Catalyzed alkylation of halopyridinates in the absence of added organic

  摘要：

  本发明描述了一种制备O-烷基化卤代吡啶酮化合物的方法。该方法不需要使用额外的有机溶剂。

  公开号：

  US04701531A1

文献信息

• Catalyzed alkylation of halopyridinates
  申请人：The Dow Chemical Company

  公开号：US03969360A1

  公开（公告）日：1976-07-13

  The reaction between the alkali metal halopyridinates with the lower alkyl esters of .alpha.-chloro or bromo acetic acid (or propionic acid) to form the corresponding O-alkylated halopyridinates is catalyzed by quaternary ammonium salts. For example, methyl .alpha.-(6-chloropyridinyloxy)acetate was prepared in excellent yield by reacting sodium 6-chloropyridinate with excess methyl .alpha.-chloroacetate in the presence of 2 mole percent of benzyl triethyl ammonium chloride.

  碱金属卤代吡啶酸盐与α-氯或溴乙酸酯（或丙酸酯）发生反应，形成相应的O-烷基化卤代吡啶酸盐，该反应由季铵盐催化。例如，通过在过量甲基α-氯乙酸酯存在下，与苯甲基三乙基铵氯化物的2摩尔百分比反应，制备了甲基α-(6-氯吡啶氧基)乙酸酯，收率极高。
• Process for preparing phosphorothioates and phenylphosphonothioates
  申请人：The Dow Chemical Company

  公开号：US04016225A1

  公开（公告）日：1977-04-05

  Mixtures of (1) a quaternary ammonium salt(s) and (2) 1,4-diazabicyclo[2.2.2]octane are novel catalysts in the process of reacting an alkali metal phenate, pyridinate or pyrimidiate with an O,O-dialkyl phosphorochloridothioate or O-alkyl phenylphosphonochloridothioate to produce the corresponding phosphorothioates and phenylphosphonothioates. The process is conducted under alkaline conditions in a liquid reaction medium. As an example, O,O-diethyl 0-(3,5,6-trichloro-2-pyridyl)phosphorothioate is prepared in excellent yields and purity by reacting sodium 3,5,6-trichloropyridinate with O,O-diethyl phosphorochloridothioate in a stirred methylene chloride-water reaction medium in the presence of a catalytic amount of benzyltriethylammonium chloride and 1,4-diazabicyclo[2.2.2]octane.

  混合物（1）季铵盐和（2）1,4-二氮杂双环[2.2.2]辛烷是在碱性条件下，在液态反应介质中反应碱金属苯酚盐，吡啶盐或嘧啶盐与O,O-二烷基磷酰氯硫代酸酯或O-烷基苯基膦酸氯硫代酸酯以产生相应的磷酸硫代酯和苯基膦酸硫代酯的新型催化剂。例如，通过在搅拌的氯甲烷-水反应介质中，在苄基三乙基铵氯和1,4-二氮杂双环[2.2.2]辛烷的催化下，将三氯吡啶钠与O,O-二乙基磷酰氯硫代酸酯反应，可以制备出优良的产率和纯度的O,O-二乙基0-(3,5,6-三氯-2-吡啶基)磷酸硫代酯。
• 2-Pyridinol compositions and methods of use as anabolic agents
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0271607A1

  公开（公告）日：1988-06-22

  A method of producing an anabolic response in animals selected from the group of swine, cattle, sheep or poultry comprising administering to the animal an anabolically effective amount of one or a mixture of two or more compounds of the following formula wherein     X¹, X² and X³ independently represent halogen, preferably chloro;     A represents hydrogen, alakali metal, alkaline earth metal, zinc, iron, manganese or     -Z; and     Z represents C₁-C₁₁ alkyl, C₁-C₁₁ haloalkyl or C₁-C₁₁ hydroxyalkyl is disclosed. The anabolic response is exhibited by one or more of the following: an increased growth rate, increased milk production, increased protein content, increased fiber production, improved reproductive performance, and increased feed conversion efficiency. Also claimed are feed composi­tions containing the active compounds.

  一种在选自猪、牛、羊或家禽的动物体内产生合成代谢反应的方法，包括给动物施用合成代谢有效量的一种或两种或两种以上下式化合物的混合物 其中 X¹、X² 和 X³ 各自代表卤素，最好是氯； A 代表氢、碱金属、碱土金属、锌、铁、锰或其它金属。 -Z；以及 Z 代表 C₁-C₁₁烷基、C₁-C₁₁卤代烷基或 C₁-C₁₁羟基烷基。同化反应表现为以下一个或多个方面：生长速度提高、产奶量提高、蛋白质含量提高、纤维产量提高、繁殖性能提高以及饲料转化效率提高。此外，还公开了含有活性化合物的饲料组合物。
• Process for preparing phosphorothioates and phosphates and phosphonothioates and phosphonates
  申请人：DOWELANCO

  公开号：EP0307501A1

  公开（公告）日：1989-03-22

  Certain phenyl and N-heterocyclic phosphoro­thioates and phosphonothioates and phosphates are pre­pared by the reaction of an appropriate alkali metal or alkaline earth metal -O-phenyl or N-heterocyclic compound with an appropriate phosphorochloridate, phosphorochloridothioate, phosphonochloridate or phosphonochloridothioate under alkaline conditions in the presence of a tertiary amine catalyst and a nonionic surfactant having an HLB Value of from 1 to 20, preferably 5 to 15, in a two-phase system, one phase being primarily the phosphorate or phosphonate reactant and a complex thereof with the tertiary amine catalyst and the other phase being an aqueous reaction medium comprising water, a buffer system, and the alkali metal or alkaline earth metal-O-phenyl or -O-N-­heterocyclic compound, in the substantial or complete absence of an organic solvent the aqueous reaction medium being maintained at pH 10 to 12 by the buffer system

  某些苯基和 N-杂环硫代磷酸酯、硫代磷酸酯和磷酸盐的制备方法是：适当的碱金属或碱土金属-O-苯基或 N-杂环化合物与适当的氯代磷酸酯、硫代磷酸酯、氯代磷酸酯或硫代磷酸酯在碱性条件下，在叔胺催化剂和 HLB 值为 1 至 20 的非离子表面活性剂存在下进行反应、最好是 5 至 15，在两相体系中，一相主要是磷酸盐或膦酸盐反应物及其与叔胺催化剂的络合物，另一相是水反应介质，包括水、缓冲体系和碱金属或碱土金属-O-苯基或-O-N-杂环化合物，在基本上或完全没有有机溶剂的情况下，水反应介质的 pH 值由缓冲体系保持在 10 至 12 之间
• Catalyzed alkylation of halopyridinates in the absence of added organic solvents
  申请人：DOWELANCO

  公开号：EP0269884B1

  公开（公告）日：1991-09-25