E-2-methoxyimino-N-methyl-2-[2-(4-methylphenoxy)phenyl]-acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: E-2-methoxyimino-N-methyl-2-[2-(4-methylphenoxy)phenyl]-acetamide
• 英文别名: E-2-methoxyimino-N-methyl-2-[2-(4-methylphenoxy)-phenyl]acetamide；(E)-N-methyl-2-[2-(4-tolyloxy)phenyl]-2-methoxyiminoacetamide；(2E)-2-methoxyimino-N-methyl-2-[2-(4-methylphenoxy)phenyl]acetamide
• 化学式: C₁₇H₁₈N₂O₃
• 分子量: 298.342
• InChiKey: HSQOMBPMLGKPEJ-KNTRCKAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲基二苯基醚 生成 E-2-methoxyimino-N-methyl-2-[2-(4-methylphenoxy)phenyl]-acetamide
  参考文献：
  名称：

  Alkoxyiminoacetamide derivatives and their use as fungicides

  摘要：

  用于农业用途的杀菌组合物，包括以下化合物：其中R.sup.1和R.sup.2分别为氢、较低烷基或环烷基；R.sup.3为较低烷基或环烷基；R.sup.4和R.sup.5分别为氢、较低烷基、较低烷氧基、卤素取代的较低烷基、较低烷基取代的硅烷基、卤素或硝基；A代表不饱和碳氢基团、卤素取代的不饱和碳氢基团、苯基或杂环基团，其中苯基和杂环基团可以选择性地取代不超过三个取代基；Z为--CH.sub.2 --、--CH(OH)--、--CO--、--O--、--S--、--NR--（R为氢或较低烷基）、--CH.sub.2 CH.sub.2 --、--CH.dbd.CH--、--CH.sub.2 O--、--CH.sub.2 S--、--CH.sub.2 SO--、--OCH.sub.2 --、--SCH.sub.2 --或--SOCH.sub.2 --。

  公开号：

  US05185342A1

文献信息

• Process for producing alkoxyiminoacetamide compounds and intermediates
  申请人：Shionogi & Co., Ltd.

  公开号：US05650539A1

  公开（公告）日：1997-07-22

  A compound of the formula [I] ##STR1## wherein X is hydrogen, lower alkyl, lower alkoxy or halogen; R is lower alkyl; and .about. is any configuration of E-isomer, Z-isomer or a mixture thereof is produced by reacting a compound of the formula ##STR2## wherein X and .about. are defined above, W is --CN or --COOR; and R is a lower alkyl, with methylamine in the presence of methanol. The compound [I] is useful for an agricultural fungicide. An intermediate used for producing the compound [I] is also disclosed.

  化合物的公式为[I] ##STR1## 其中X为氢、低碳基、低烷氧基或卤素；R为低碳基；.about.为E-异构体、Z-异构体或其混合物中的任何构型，通过在甲醇存在下将化合物的公式 ##STR2## 与甲基胺反应生成。化合物[I]可用作农业杀菌剂。还公开了用于制备化合物[I]的中间体。
• Process for producing methoxyiminoacetamide compounds and intermediates
  申请人：Shionogi & Co., Ltd.

  公开号：US05380913A1

  公开（公告）日：1995-01-10

  A compound of the formula [I]: ##STR1## wherein X is hydrogen, lower alkyl, lower alkoxy or halogen; is any configuration of E-isomer, Z-isomer or a mixture thereof is produced by reacting a compound of the formula [II] ##STR2## wherein X and are as defined above; W is --CN or --COOR; and R is a lower alkyl, with methylamine in the presence of methanol. The compound [I] is useful for an agricultural fungicide. An intermediate used for producing the compound [I] is also disclosed.

  公式[I]的化合物：##STR1## 其中X为氢、低烷基、低烷氧基或卤素；E-异构体、Z-异构体或其混合物的任何构型可通过在甲醇存在下用公式[II]的化合物：##STR2## 其中X和如上定义；W为-CN或-COOR；R为低烷基，与甲胺反应制备而成。化合物[I]用作农业杀菌剂。还公开了用于制备化合物[I]的中间体。
• Process for producing methoxyminoacetamide compounds
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0605392A1

  公开（公告）日：1994-07-06

  A process for producing a compound of the formula [I]: wherein X is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; and - is any configuration of E-isomer, Z-isomer or a mixture thereof, which comprises reacting a compound of the formula [V]: wherein X and - are as defined above and M is hydrogen or an alkali metal, with a compound of the formula [lV]: wherein L is halogen or -OS020CH3.

  一种生产式[I]化合物的工艺：式中X为氢、C1-C6烷基、C1-C6烷氧基或卤素；-为E-异构体、Z-异构体或其混合物的任意构型，该工艺包括将式[V]化合物：式中X和-如上定义，M为氢或碱金属，与式[lV]化合物：式中L为卤素或-OS020CH3反应。
• Process for producing E-isomers of methoxyminoacetamide compounds
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0606924A1

  公开（公告）日：1994-07-20

  A process for producing a E-isomer of the formula: wherein X is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; A is -CONHCH3 or -COOR; and R is C1-C6 alkyl comprises reacting a Z-isomer of the formula [VI]: wherein X, A and R are as defined above, with an acid in a C1-C6 alcohol.

  一种生产式中 E-异构体的工艺： 其中X是氢、C1-C6烷基、C1-C6烷氧基或卤素；A是-CONHCH3或-COOR；R是C1-C6烷基，包括使式[VI]的Z-异构体反应： 其中 X、A 和 R 如上定义，与 C1-C6 醇中的酸反应。
• Process for the preparation of Alkoxyiminoacetamide derivatives and an intermediate therefor
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0629609A1

  公开（公告）日：1994-12-21

  A process for preparing a compound of the formula: wherein A is a phenyl group or a heterocyclic group, said phenyl group and said heterocyclic group being optionally substituted with not more than three substituents, which comprises reacting a compound of the formula: with an aryl halide in the presence of a base. The resulting compound (A) is useful as a fungicide. There is also disclosed a compound of the formula:

  一种制备式化合物的工艺： 其中 A 是苯基或杂环基团，所述苯基和杂环基团可任选被不超过三个取代基取代，该工艺包括使以下式子的化合物发生反应 与芳基卤化物在碱存在下反应。所得化合物（A）可用作杀真菌剂。还公开了一种式化合物：