4-fluorophenylmethylene-2-naphthylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-fluorophenylmethylene-2-naphthylamine
• 化学式: C₁₇H₁₂FN
• 分子量: 249.287
• InChiKey: IMRYDOQIBCOIKL-XDHOZWIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.73
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-fluorophenylmethylene-2-naphthylamine 在 盐酸 作用下， 以 乙醇 、 水 、 硝基苯 为溶剂， 反应 3.0h， 生成 N-(4-fluorobenzyl)naphthalen-2-amine
  参考文献：
  名称：

  β-含氧酸酯在苯并[f]喹啉衍生物的合成中

  摘要：

  Condensation of ethyl acetoacetate and ethyl 3-oxo-3-(2-furyl-, 2-quinolyl-, 3-pyridyl)propanoates with azomethines of 2-naphthylamine series led to the formation of ethyl (3-arylbenzo[f]quinol-1-yl)acetates and of esters of the corresponding 3-aryl-1-heteryl-2-benzo[f]quinolylcarboxylic acids. The intermediate reaction products were isolated: ethyl 5-(2-naphthylamino)-3-oxo-5-phenylpentanoate, 2-[(aryl)(2-naphthylamino)methyl]-3-heteryl-3-oxopropanoates, dihydro and tetrahydro derivatives of benzoquinolylacetic and benzoquinolinecarboxylic acids.

  DOI：

  10.1134/s1070428007050119
• 作为产物：
  描述：

  2-萘胺 、 对氟苯甲醛 以 乙醇 为溶剂， 生成 4-fluorophenylmethylene-2-naphthylamine
  参考文献：
  名称：

  Condensation of fluorosubstituted benzaldehydes with amines and cyclic 1,3-diketones

  摘要：

  Condensation of fluorosubstituted benzaldehydes with 2-naphthyl or 6-quinolylamine and cyclic beta-diketones (,3-cyclohexanedione, dimedone, and 1,3-indandione) provided new fluoroderivatives of benzo[a]acridine, 4,7-phenanthroline, and benzo[f]indeno[1,2-b]quinoline. Forming in the course of the reaction fluorophenylmethylene-2-naphthyl-(or 6-quinolyl)amines, arylbis(cyclohexane-1,3-dion-2-yl)methanes, and 2-(fluorophenylmethylene)- 1,3-indandiones were isolated.

  DOI：

  10.1134/s107042800611011x

文献信息

• Synthesis of benzo[f]quinoline derivatives by condensation of N-arylmethylene-2-naphthylamines with acetylcyclohexane and 1-acetylcyclohexene
  作者：V. I. Grachek

  DOI：10.1007/s11176-005-0094-4

  日期：2004.11

  N -Arylmethylene-2-naphthylamines react with acetylcyclohexane and 1-acetylcyclohexene under mild conditions to afford 2-aryl-2-(2-naphthylamino)ethyl cyclohexyl and 1-cyclohexenyl ketones, respectively. Under more severe conditions (110°C), the reaction is accompanied by cyclization with formation of 3-aryl-1-cyclohexyl(or 1-cyclohexenyl)benzo[ f ]quinolines. Proper choice of the amount of catalyst

  N- 芳基亚甲基-2-萘胺在温和条件下与乙酰基环己烷和1-乙酰基环己烯反应，分别得到2-芳基-2-（2-萘基氨基）乙基环己基和1-环己烯基酮。在更苛刻的条件下（110℃），反应伴随环化，形成3-芳基-1-环己基（或1-环己烯基）苯并[ f ]喹啉。催化剂，温度和反应时间的量的适当选择允许中间体3-芳基-1-环己基（或1-环己烯基）-3,4-二氢苯并[隔离 ˚F 〕喹啉。
• Cosmetic and personal care compositions
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20020176834A1

  公开（公告）日：2002-11-28

  Cosmetic or personal care compositions comprise: a hair styling polymer having one or more groups selected from acidic functional groups, anionic groups derived from the acidic functional groups or a mixture of said groups; a partially or fully fluorinated compound having one or more groups selected from amino groups, acid salts of the amino groups or a mixture of said groups, wherein the partially or fully fluorinated compound comprises an aromatic ring; and a cosmetically acceptable diluent or carrier. The compositions are particularly effective under high humidity conditions.

  化妆品或个人护理组合物包括：具有一个或多个基团的头发定型聚合物，这些基团选自酸性官能团、酸性官能团衍生的阴离子基团或上述基团的混合物；具有一个或多个基团的部分或完全氟化化合物，这些基团选自氨基基团、氨基基团的酸式盐或上述基团的混合物，其中部分或完全氟化化合物包含一个芳香环；以及化妆品可接受的稀释剂或载体。这些组合物在高湿度条件下尤其有效。
• Kozlov; Sauts; Gusak, Russian Journal of Organic Chemistry, 2000, vol. 36, # 4, p. 531 - 538
  作者：Kozlov、Sauts、Gusak

  DOI：——

  日期：——
• Kozlov; Popova, Russian Journal of Organic Chemistry, 1999, vol. 35, # 4, p. 603 - 605
  作者：Kozlov、Popova

  DOI：——

  日期：——
• Three-component condensation of 2-naphthylamine with aromatic aldehydes and 5-(2-furyl)-1,3-cyclohexanedione
  作者：N. G. Kozlov、K. N. Gusak、V. V. Skatetskii

  DOI：10.1134/s1070428006010179

  日期：2006.1

  Three-component condensation of 5-(2-furyl)-1,3-cyclohexanedione with 2-naphthylamine and aromatic or heteroaromatic aldehydes afforded 12-aryl(hetaryl)-9-(2-furyl)-7,8,9,10,11,12-hexahydrobenzo[a]-acridin-11-ones possessing two asymmetric carbon atoms (C-9 and C-12). The products were found to be formed as mixtures of diastereoisomers.