2-methyl-4-(4-phenoxyphenyl)thiazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-4-(4-phenoxyphenyl)thiazole
• 英文别名: 2-methyl-4-(4-phenoxy-phenyl)-thiazole；2-Methyl-4-(4-phenoxy-phenyl)-thiazol；2-Methyl-4-(p-phenoxyphenyl)-thiazol；2-Methyl-4-(4-phenoxyphenyl)-1,3-thiazole；2-methyl-4-(4-phenoxyphenyl)-1,3-thiazole
• 化学式: C₁₆H₁₃NOS
• 分子量: 267.351
• InChiKey: KEZNAHVFQVOFHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  50.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴-1-(4-苯氧基苯基)乙酮 、 硫代乙酰胺 在 tert-butylammonium hexafluorophosphate(V) 作用下， 以 甲醇 为溶剂， 反应 0.23h， 以92%的产率得到2-methyl-4-(4-phenoxyphenyl)thiazole
  参考文献：
  名称：

  A Rapid and High-Yielding Synthesis of Thiazoles and Aminothiazoles Using Tetrabutylammonium Salts

  摘要：

  A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of tetra butylammonium hexafluorophosphate (Bu4NPF6) at room temperature was developed. The products having high yields were formed rapidly (within 15 min). The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, H-1 NMR, C-13 NMR spectroscopy and elemental analysis data.

  DOI：

  10.3987/com-10-12067

文献信息

• CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS
  申请人：Singh Rajinder

  公开号：US20100130486A1

  公开（公告）日：2010-05-27

  The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.

  本发明涵盖具有公式I或II的化合物，以及使用这些化合物治疗抑制PKC和PKD在治疗上有用的情况的组合物和方法。
• US8993585B2
  申请人：——

  公开号：US8993585B2

  公开（公告）日：2015-03-31
• A Rapid and High-Yielding Synthesis of Thiazoles and Aminothiazoles Using Tetrabutylammonium Salts
  作者：Erdal Kocabas、Ahmet Burak Sarıguney、Ahmet Coskun

  DOI：10.3987/com-10-12067

  日期：——

  A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of tetra butylammonium hexafluorophosphate (Bu4NPF6) at room temperature was developed. The products having high yields were formed rapidly (within 15 min). The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, H-1 NMR, C-13 NMR spectroscopy and elemental analysis data.