N⁴-(2,7-dichloro-quinazolin-4-yl)-N¹,N¹-diethylpentane-1,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N⁴-(2,7-dichloro-quinazolin-4-yl)-N¹,N¹-diethylpentane-1,4-diamine
• 英文别名: N4-(2,7-dichloro-quinazolin-4-yl)-N1,N1-diethyl-pentane-1,4-diamine；4-N-(2,7-dichloroquinazolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
• 化学式: C₁₇H₂₄Cl₂N₄
• 分子量: 355.31
• InChiKey: DTKJHQNXRGXQHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  41
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-氯喹啉-2,4(1氢,3氢)-二酮 在 N,N-二甲基苯胺 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 11.0h， 生成 N⁴-(2,7-dichloro-quinazolin-4-yl)-N¹,N¹-diethylpentane-1,4-diamine
  参考文献：
  名称：

  Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones☆

  摘要：

  A series of 2-sec-amino-3H-quinazolin-4-ones (4a-p) and 4-sec-amino-2-chloroquinazolines (5a-b) have been synthesized by nucleophilic substitution reaction of 2-chloro-4(3H)-quinazolones (3) and 2,4-dichloroquinazolines (2) with amines, respectively. Most of the synthesized compounds were evaluated for antihyperglycemic activity but only 4a,b,d,j,o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00142-1

文献信息

• 4-Amino-quinazolines
  申请人：Mederski Werner

  公开号：US20060019974A1

  公开（公告）日：2006-01-26

  Quinazolines of the formula (I) in which R, R 1 , R 2 , R 3 , R 4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

  公式（I）中的喹唑啉，其中R，R1，R2，R3，R4和Y具有专利权要求1中指示的含义，以其盐或溶剂合物作为糖蛋白IbIX拮抗剂。
• 4-amino-quinazolines
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：US07547702B2

  公开（公告）日：2009-06-16

  Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein 1bIX antagonists.

  公式（I）中R，R1，R2，R3，R4和Y的含义如专利权要求书1所示，以及它们的盐或溶剂合物作为糖蛋白1bIX拮抗剂的喹唑啉。
• US7547702B2
  申请人：——

  公开号：US7547702B2

  公开（公告）日：2009-06-16
• Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones☆
  作者：Vishnu Ji Ram、Farhanullah、Brajendra K Tripathi、Arvind K Srivastava

  DOI：10.1016/s0968-0896(03)00142-1

  日期：2003.5.29

  A series of 2-sec-amino-3H-quinazolin-4-ones (4a-p) and 4-sec-amino-2-chloroquinazolines (5a-b) have been synthesized by nucleophilic substitution reaction of 2-chloro-4(3H)-quinazolones (3) and 2,4-dichloroquinazolines (2) with amines, respectively. Most of the synthesized compounds were evaluated for antihyperglycemic activity but only 4a,b,d,j,o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models. (C) 2003 Elsevier Science Ltd. All rights reserved.