thiocarbonic acid pyridin-3-yl ester naphthalen-2-yl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: thiocarbonic acid pyridin-3-yl ester naphthalen-2-yl ester
• 英文别名: Naphthalen-2-yloxy(pyridin-3-yloxy)methanethione
• 化学式: C₁₆H₁₁NO₂S
• 分子量: 281.335
• InChiKey: PATBIVOHRQYKHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  O-naphth-2-yl benzotriazole-1-carbothioate 、 3-羟基吡啶 在 sodium hydride 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以72%的产率得到thiocarbonic acid pyridin-3-yl ester naphthalen-2-yl ester
  参考文献：
  名称：

  Benzotriazole-Assisted Thioacylation

  摘要：

  Benzotriazole reagents for thioacylation (RCSBt), thiocarbamoylation (RR'NCSBt), aryl/alkoxythioacylation (ROCSBt), and aryl/alkylthiothioacylation (RSCSBt) are synthesized, and their utility is assessed by syntheses of representative heteroaryl thioureas 3a-g, thioamides 15a-s, thionoesters 16a-h, thiocarbamates 17a-e, dithiocarbamates 18a-d, thiocarbonates 19a-c, and dithiocarbonates 20a-c.

  DOI：

  10.1021/jo050670t

文献信息

• Benzotriazole-Assisted Thioacylation
  作者：Alan R. Katritzky、Rachel M. Witek、Valerie Rodriguez-Garcia、Prabhu P. Mohapatra、James W. Rogers、Janet Cusido、Ashraf A. A. Abdel-Fattah、Peter J. Steel

  DOI：10.1021/jo050670t

  日期：2005.9.1

  Benzotriazole reagents for thioacylation (RCSBt), thiocarbamoylation (RR'NCSBt), aryl/alkoxythioacylation (ROCSBt), and aryl/alkylthiothioacylation (RSCSBt) are synthesized, and their utility is assessed by syntheses of representative heteroaryl thioureas 3a-g, thioamides 15a-s, thionoesters 16a-h, thiocarbamates 17a-e, dithiocarbamates 18a-d, thiocarbonates 19a-c, and dithiocarbonates 20a-c.