N-ethyl-N-(p-trifluoromethylphenyl)aniline

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethyl-N-(p-trifluoromethylphenyl)aniline
• 英文别名: N-ethyl-N-phenyl-4-(trifluoromethyl)aniline
• 化学式: C₁₅H₁₄F₃N
• 分子量: 265.278
• InChiKey: VBEFIPGKYDGRJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对溴三氟甲苯 、 N-乙基苯胺 在 tris(dibenzylideneacetone)dipalladium (0) 、 (-)-triphenylphosphine(dicarbonyl)chromium 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以95%的产率得到N-ethyl-N-(p-trifluoromethylphenyl)aniline
  参考文献：
  名称：

  Palladium-Catalyzed Amination of Aryl Bromides Utilizing Arene−Chromium Complexes as Ligands

  摘要：

  The arene-chromium complexes of o-diphenylphosphino alpha-phenylethylamine or a-phenylethyl methyl ether derivatives were examined with regard to their activity as ligands for palladium(0)-catalyzed aryl amination of aryl bromides with a variety of amines. Both steric and electronic factors were found to be significant for the efficient palladium-catalyzed aryl amination reactions. Modulation of the inductive capacity of the arylphosphine atom was achieved by photoinduced ligand exchange of one carbonyl of the chromium tripode in the presence of electron-donating triphenylphosphine or phosphite. Among these arene-chromium ligands, the use of the monophosphineor monophosphite-(dicarbonyl)chromium of N,N-dimethyl alpha-(o-diphenylphosphino)phenylethylamine and methyl alpha-(o-diphenylphosphino)phenylethyl ether produced the palladium(0)-catalyzed aryl amination products with cyclic amines or acyclic secondary amines in high yields; the corresponding strong electron-withdrawing tricarbonylchromium complex resulted in a modest yield of the aryl amination.

  DOI：

  10.1021/jo981327+

文献信息

• Glycine Transporter-1 Inhibitors
  申请人：Hitchcock Stephen A.

  公开号：US20100298341A1

  公开（公告）日：2010-11-25

  The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本发明提供了一些甘氨酸转运体1（以下简称GlyT-1）抑制剂化合物，因此可用于治疗可通过抑制GlyT1治疗的疾病，如与精神分裂症、注意力缺陷多动障碍（ADHD）、轻度认知障碍（MCI）等相关的认知障碍。还提供了含有这些化合物的制药组合物和制备这些化合物的方法。
• METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES
  申请人：Neurochem (International) Limited

  公开号：EP1828111A2

  公开（公告）日：2007-09-05
• US8258306B2
  申请人：——

  公开号：US8258306B2

  公开（公告）日：2012-09-04
• [EN] METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES<br/>[FR] PROCEDES ET COMPOSITIONS FLUOREES POUR LE TRAITEMENT DE MALADIES ASSOCIEES AUX AMYLOIDES
  申请人：NEUROCHEM INT LTD

  公开号：WO2006059252A2

  公开（公告）日：2006-06-08

  [EN] Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease. Also described are methods, compounds, pharmaceutical compositions and kits for detecting, diagnosing, monitoring and treating or preventing amyloid-related disease.
  [FR] L'invention concerne des procédés, des composés, des compositions pharmaceutiques et des kits destinés au traitement ou à la prévention de maladies associées aux amyloïdes. L'invention concerne également des procédés, des composés, des compositions pharmaceutiques et des kits destinés à la détection, au diagnostic, au contrôle et au traitement ou à la prévention de maladies associées aux amyloïdes.
• Palladium-Catalyzed Amination of Aryl Bromides Utilizing Arene−Chromium Complexes as Ligands
  作者：Ken Kamikawa、Suguru Sugimoto、Motokazu Uemura

  DOI：10.1021/jo981327+

  日期：1998.11.1

  The arene-chromium complexes of o-diphenylphosphino alpha-phenylethylamine or a-phenylethyl methyl ether derivatives were examined with regard to their activity as ligands for palladium(0)-catalyzed aryl amination of aryl bromides with a variety of amines. Both steric and electronic factors were found to be significant for the efficient palladium-catalyzed aryl amination reactions. Modulation of the inductive capacity of the arylphosphine atom was achieved by photoinduced ligand exchange of one carbonyl of the chromium tripode in the presence of electron-donating triphenylphosphine or phosphite. Among these arene-chromium ligands, the use of the monophosphineor monophosphite-(dicarbonyl)chromium of N,N-dimethyl alpha-(o-diphenylphosphino)phenylethylamine and methyl alpha-(o-diphenylphosphino)phenylethyl ether produced the palladium(0)-catalyzed aryl amination products with cyclic amines or acyclic secondary amines in high yields; the corresponding strong electron-withdrawing tricarbonylchromium complex resulted in a modest yield of the aryl amination.