tris(2-pyridylmethyl)amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tris(2-pyridylmethyl)amine
• 英文别名: tpma；Tris(pyridin-4-ylmethyl)amine；1-pyridin-4-yl-N,N-bis(pyridin-4-ylmethyl)methanamine
• 化学式: C₁₈H₁₈N₄
• 分子量: 290.368
• InChiKey: QPDWAVKNXPQOOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tris(2-pyridylmethyl)amine 、 溴代十二烷 以 乙腈 为溶剂， 以78%的产率得到
  参考文献：
  名称：

  下一代基于吡啶鎓的multiQAC防腐剂的开发

  摘要：

  与市售的吡啶鎓杀菌十六烷基吡啶鎓氯化物（CPC）相比，制备了一系列18个二吡啶和三吡啶鎓两亲物，并测试了其抗菌活性和裂解能力。对革兰氏阳性和革兰氏阴性细菌（包括两种耐甲氧西林的金黄色葡萄球菌）进行了评估（MRSA）菌株。尽管2Pyr-11,11被确定为迄今为止报道的最有效的抗菌季铵化合物（QAC）之一，对测试的六种细菌中的五种具有纳摩尔抑制作用，但三吡啶鎓两亲物的生物活性没有比双吡啶鎓显着提高。观察到同行。但是，本文介绍的多阳离子QAC（multiQAC）确实比单阳离子CPC具有明显的优势。尽管观察到类似的红细胞溶解现象，但对革兰氏阴性菌和耐药金黄色葡萄球菌菌株均具有优异的活性，因此发现了四种具有有利治疗指标的基于吡啶鎓的multiQAC。

  DOI：

  10.1002/cmdc.201600546
• 作为产物：
  描述：

  4-氯甲基吡啶 在 ammonium hydroxide 、 N-butyl,N-hexylpyrrolidinium bromide 作用下， 反应 1.0h， 以98.5%的产率得到tris(2-pyridylmethyl)amine
  参考文献：
  名称：

  N,N-二烷基吡咯烷溴盐离子液体制备方法及其应用

  摘要：

  本发明涉及一种N,N‑二烷基吡咯烷溴盐离子液体制备方法及其应用，该方法以N‑烷基四氢吡咯和烷基醇为原料通过电解方式实现，在电解槽中设置有阳离子交换膜，阳离子交换膜将电解槽分成阴极室与阳极室，完成电解后取出阴极电解液，分离纯化，得到N,N‑二烷基吡咯烷类溴盐离子液体，该制备方法工艺简单，条件温和，纯度和收率较高。将N,N‑二烷基吡咯烷溴盐离子液体作为溶剂，以氯甲基吡啶的盐酸盐和氨水为原料，合成三吡啶甲基胺类化合物，该制备方法产率和纯度高，无需后续分离，成本低，绿色环保，离子液体可以反复循环使用，适合于工业化生产。

  公开号：

  CN109825848A

文献信息

• [EN] A PROCESS FOR THE SYNTHESIS OF CARBON LABELED ORGANIC COMPOUNDS<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE COMPOSÉS ORGANIQUES MARQUÉS AU CARBONE
  申请人：COMMISSARIAT ENERGIE ATOMIQUE

  公开号：WO2019193068A1

  公开（公告）日：2019-10-10

  The present invention relates to a process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group. The present invention also concerns the use of carbon labeled organic compounds containing a carbon labeled carboxyl group obtained by the process of the invention, in the manufacture of pharmaceuticals and agrochemicals, in particular pharmaceuticals and agrochemicals having a free carboxylic acid functionality. Another aspect of the invention relates to a process for manufacturing labeled pharmaceuticals and agrochemicals, in particular pharmaceuticals and agrochemicals having a free carboxylic acid functionality, comprising a step of synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl obtained by the process of the invention A still another aspect of the invention further relates to a process for producing tracers and radiotracers, characterized in that it comprises a step of synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group obtained by the process of the invention.

  本发明涉及一种合成含有碳标记羧基的碳标记有机化合物的方法。本发明还涉及使用通过本发明方法获得的含有碳标记羧基的碳标记有机化合物，在制药和农药制造中的应用，特别是在具有自由羧基酸功能的制药和农药中的应用。发明的另一个方面涉及一种制造标记制药品和农药的方法，特别是制造具有自由羧基酸功能的制药品和农药的方法，包括通过本发明方法获得的含有碳标记羧基的碳标记有机化合物的合成步骤。发明的另一个方面进一步涉及一种生产示踪剂和放射示踪剂的方法，其特点在于包括通过本发明方法获得的含有碳标记羧基的碳标记有机化合物的合成步骤。
• [EN] POLYCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS AND METHODS USING SAME<br/>[FR] COMPOSÉS AMPHIPHILES POLYCATIONIQUES UTILES EN TANT QU'AGENTS ANTIMICROBIENS ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV TEMPLE

  公开号：WO2018081347A1

  公开（公告）日：2018-05-03

  The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.

  本发明包括作为抗微生物剂有用的新型多阳离子两性化合物。本发明还包括用于从表面去除微生物和/或生物膜嵌入微生物的方法。本发明还包括用于预防或减少微生物和/或生物膜嵌入微生物在表面上生长或繁殖的组合物和方法。
• A PROCESS FOR THE SYNTHESIS OF CARBON LABELED ORGANIC COMPOUNDS
  申请人：Commissariat à l'Energie Atomique et aux Energies Alternatives

  公开号：EP3549927A1

  公开（公告）日：2019-10-09

  The present invention relates to a process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group. The present invention also concerns the use of carbon labeled organic compounds containing a carbon labeled carboxyl group obtained by the process of the invention, in the manufacture of pharmaceuticals and agrochemicals, in particular pharmaceuticals and agrochemicals having a free carboxylic acid functionality. Another aspect of the invention relates to a process for manufacturing labeled pharmaceuticals and agrochemicals, in particular pharmaceuticals and agrochemicals having a free carboxylic acid functionality, comprising a step of synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl obtained by the process of the invention A still another aspect of the invention further relates to a process for producing tracers and radiotracers, characterized in that it comprises a step of synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group obtained by the process of the invention.

  本发明涉及一种合成含有碳标记羧基的碳标记有机化合物的工艺。 本发明还涉及将通过本发明工艺获得的含有碳标记羧基的碳标记有机化合物用于制造药物和农用化学品，特别是具有游离羧酸官能团的药物和农用化学品。 本发明的另一方面涉及一种制造标记药物和农用化学品，特别是具有游离羧酸官能团的药物和农用化学品的工艺，包括合成含有本发明工艺获得的碳标记羧基的碳标记有机化合物的步骤。 本发明的另一个方面还涉及一种生产示踪剂和放射性示踪剂的工艺，其特征在于该工艺包括合成通过本发明工艺获得的含有碳标记羧基的碳标记有机化合物的步骤。
• Polycationic amphiphiles as antimicrobial agents and methods using same
  申请人：Temple University-Of The Commonwealth System of Higher Education

  公开号：US11111216B2

  公开（公告）日：2021-09-07

  The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.

  本发明包括可用作抗菌剂的新型多阳离子两亲化合物。本发明还包括用于从表面清除微生物和/或生物膜嵌入微生物的方法。本发明还包括用于防止或减少表面微生物和/或生物膜嵌入微生物生长或增殖的组合物和方法。
• Introduction of Flexibility into a Metal–Organic Framework to Promote Hg(II) Capture through Adaptive Deformation
  作者：Jiayue Tian、Chengdan Shi、Cao Xiao、Feilong Jiang、Daqiang Yuan、Qihui Chen、Maochun Hong

  DOI：10.1021/acs.inorgchem.0c02781

  日期：2020.12.21

  The development of a practical Hg(II) adsorbent is highly important for both environmental protection and public health. Herein, an adaptive metal-organic framework (MOF; FJI-H30) has been prepared from a highly flexible ligand [tris(pyridin-4-ylmethyl)amine] and Co(SCN)₂ with cheap Hg(II) adsorption sites (SCN^- groups) that not only has excellent chemical stability but also can capture Hg(II) from aqueous solution with high adsorption capacity (705 mg g^-1). Moreover, it also has good anti-interference ability and can be used repeatedly and large-scale prepared. Further researches demonstrate that the relatively high Hg(II) adsorption capacity originates from the adsorbed Hg(II)-induced deformation of FJI-H30, and such an adaptive deformation will reduce the potential repulsive forces between the adsorbed Hg(II) ions, enabling almost all Hg(II) absorption sites to adsorb Hg(II) ions. Finally, how to induce the deformation of FJI-H30 by adsorbed Hg(II) also has been studied in detail. Our work not only provides a practical Hg(II) adsorbent for wastewater treatment but also offers a novel strategy for the design of novel MOFs for efficient heavy-metal-ion removal.