2-[[3-(Trifluoromethyl)phenyl]sulfonylamino]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[3-(Trifluoromethyl)phenyl]sulfonylamino]acetamide
• 化学式: C₉H₉F₃N₂O₃S
• mdl: MFCD20538831
• 分子量: 282.24
• InChiKey: LIWDASZPWLXRGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  97.6
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS
  申请人：INCYTE CORPORATION

  公开号：EP1565436A2

  公开（公告）日：2005-08-24
• EP1565436A4
  申请人：——

  公开号：EP1565436A4

  公开（公告）日：2007-07-18
• JP2006516145A
  申请人：——

  公开号：JP2006516145A

  公开（公告）日：2006-06-22
• [EN] 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS<br/>[FR] DERIVES DE LA 3-AMINOPYRROLIDINE MODULATEURS DES RECEPTEURS DE LA CHEMOQUINE
  申请人：INCYTE CORP

  公开号：WO2004050024A2

  公开（公告）日：2004-06-17

  The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.