去氟匹莫齐特 | 1997-93-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 去氟匹莫齐特
• 英文名称: 1-{1-[4-(4-fluoro-phenyl)-4-phenyl-butyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
• 英文别名: Desfluoro pimozide；3-[1-[4-(4-fluorophenyl)-4-phenylbutyl]piperidin-4-yl]-1H-benzimidazol-2-one
• CAS: 1997-93-9
• 化学式: C₂₈H₃₀FN₃O
• 分子量: 443.564
• InChiKey: PVCIEUVRTMSCLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MULTI-DAY DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES
  申请人：KYDONIEUS Agis

  公开号：US20150216989A1

  公开（公告）日：2015-08-06

  Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.

  揭示了用于修改生物活性物质以实现多天输送的组合物和方法，特别是通过口服或静脉注射途径。这些组合物包括将生物活性物质与具有适当长半衰期（通常超过一天）的载体结合，其中该共轭物可选地包含将载体与生物活性物质连接的间隔物。还揭示了这些共轭物的药物配方，以及延长单剂量生物活性物质输送超过一天的方法。
• Multi-Day Delivery Of Biologically Active Substances
  申请人：Kydonieus Agis

  公开号：US20110046599A1

  公开（公告）日：2011-02-24

  Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.

  本发明揭示了用于修改生物活性物质以实现多日输送的组合物和方法，特别是通过口服或静脉注射途径。这些组合物包括与具有适当长寿命（通常超过一天）的载体结合的生物活性物质，其中该共轭体可选地包含将载体与生物活性物质连接的间隔物。本发明还揭示了该共轭体的制药配方，以及延长单剂量生物活性物质输送超过一天的方法。
• US8992977B2
  申请人：——

  公开号：US8992977B2

  公开（公告）日：2015-03-31
• [EN] MULTI-DAY DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES<br/>[FR] DÉLIVRANCE SUR PLUSIEURS JOURS DE SUBSTANCES ACTIVES SUR LE PLAN BIOLOGIQUE
  申请人：SAMOS PHARMACEUTICALS LLC

  公开号：WO2009002542A1

  公开（公告）日：2008-12-31

  [EN] Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.
  [FR] La présente invention concerne des compositions et des procédés pour modifier des substances actives sur le plan biologique afin d'obtenir une délivrance sur plusieurs jours de ces substances, particulièrement par l'intermédiaire d'une administration orale ou parentérale. Les compositions renferment la substance active sur le plan biologique conjuguée à un support présentant une demi-vie d'une durée appropriée, généralement de plus d'un jour, où le conjugué contient éventuellement un espaceur liant le support à la substance active sur le plan biologique. L'invention concerne également des formulations pharmaceutiques des conjugués ainsi que des procédés pour prolonger la délivrance d'une dose unique d'une substance active sur le plan biologique pendant plus d'un jour.