2-methyl-4-chloro-6-(3-hydroxyphenylamino)-pyrimidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-4-chloro-6-(3-hydroxyphenylamino)-pyrimidine
• 英文别名: 2-Methyl-4-chloro-6-(3-hydroxyphenylamino)pyrimidine；3-[(6-chloro-2-methylpyrimidin-4-yl)amino]phenol
• 化学式: C₁₁H₁₀ClN₃O
• 分子量: 235.673
• InChiKey: XVVZOSWDUHPMQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  58
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methyl-4-chloro-6-(3-hydroxyphenylamino)-pyrimidine 、 间氨基苯甲醚 以 乙二醇乙醚 为溶剂， 反应 5.0h， 以50%的产率得到2-methyl-N-(3-hydroxyphenyl)-N'-(3-methoxyphenyl)-pyrimidine-4,6-diamine
  参考文献：
  名称：

  PREVENTIVES OR REMEDIES FOR ALZHEIMER'S DISEASE OR AMYLOID PROTEIN FIBROSIS INHIBITORS CONTAINING NITROGEN-CONTAINING HETEROARYL COMPOUNDS

  摘要：

  公开号：

  EP1473289B1
• 作为产物：
  描述：

  4,6-二羟基-2-甲基嘧啶 、 2-ethyl-1H-pyrimidine-4,6-dione 、 3-氨基苯酚 以 乙二醇乙醚 为溶剂， 反应 4.0h， 以75%的产率得到2-methyl-4-chloro-6-(3-hydroxyphenylamino)-pyrimidine
  参考文献：
  名称：

  PREVENTIVES OR REMEDIES FOR ALZHEIMER'S DISEASE OR AMYLOID PROTEIN FIBROSIS INHIBITORS CONTAINING NITROGEN-CONTAINING HETEROARYL COMPOUNDS

  摘要：

  公开号：

  EP1473289B1

文献信息

• Preventives or remidies for alzheimer's disease or amyloid protein fibrosis inhibitors containing nitrogen-containing heteroaryl compounds
  申请人：Meguro Masaki

  公开号：US20050054732A1

  公开（公告）日：2005-03-10

  The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R 1 and R 2 are H or alkyl; Z 1 and Z 2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z 3 is alkoxy, SH, alkylthio, NH 2 , mono- or di-alkylamino, OH or halogeno; Z 4 and Z 5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).

  本发明涉及预防或治疗阿尔茨海默病的药物或药物，或β淀粉样蛋白纤维形成抑制剂，其中包括通式（I）下的化合物或其药学上允许的盐作为活性成分；还涉及具有特定取代基的含氮杂环衍生物或其药学上允许的盐，其作为防治阿尔茨海默病的药物或β淀粉样蛋白纤维形成抑制剂具有价值：（其中，R1和R2是H或烷基；Z1和Z2是H，烷基，烷氧基，卤代烷基或卤素基；Z3是烷氧基，SH，烷硫基，NH2，单或双烷基氨基，OH或卤素基；Z4和Z5是H或卤素基；A是4,6-嘧啶-1,3-二基，1,3,5-三嗪-2,6-二基等）。
• Preventives or remedies for Alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound
  申请人：Meguro Masaki

  公开号：US20080182846A1

  公开（公告）日：2008-07-31

  The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R 1 and R 2 are H or alkyl; Z 1 and Z 2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z 3 is alkoxy, SH, alkylthio, NH 2 , mono- or di-alkylamino, OH or halogeno; Z 4 and Z 5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).

  本发明涉及用于预防或治疗阿尔茨海默病的药物或疗法，或者用于抑制淀粉样蛋白纤维形成的药物，其中包括通式（I）所示的化合物或其药学上允许的盐作为活性成分；以及具有特定取代基的含氮杂环衍生物或其药学上允许的盐，它们对于预防或治疗阿尔茨海默病或作为淀粉样蛋白纤维形成抑制剂非常有价值。（其中，R1和R2为H或烷基；Z1和Z2为H、烷基、烷氧基、卤代烷基或卤素；Z3为烷氧基、SH、烷基硫醇、NH2、单烷基或二烷基氨基、OH或卤素；Z4和Z5为H或卤素；A为4,6-嘧啶-1,3-二基、1,3,5-三嗪-2,6-二基等）。
• Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound
  申请人：Meguro Masaki

  公开号：US20090286794A1

  公开（公告）日：2009-11-19

  The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R 1 and R 2 are H or alkyl; Z 1 and Z 2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z 3 is alkoxy, SH, alkylthio, NH 2 , mono- or di-alkylamino, OH or halogeno; Z 4 and Z 5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).

  本发明涉及用于防治阿尔茨海默病的预防剂或治疗剂，或淀粉样蛋白纤维形成抑制剂，其包括以下通式（I）的化合物或其药理学许可盐作为活性成分；以及具有特定取代基的含氮杂芳基衍生物，或其药理学许可盐，它们作为防治阿尔茨海默病的预防剂或治疗剂，或淀粉样蛋白纤维形成抑制剂具有重要价值：（其中，R1和R2为H或烷基；Z1和Z2为H、烷基、烷氧基、卤代烷基或卤素；Z3为烷氧基、SH、烷硫基、NH2、单烷基或二烷基氨基、OH或卤素；Z4和Z5为H或卤素；A为4,6-嘧啶-1,3-二基、1,3,5-三嗪-2,6-二基等）。
• US7589105B2
  申请人：——

  公开号：US7589105B2

  公开（公告）日：2009-09-15
• US8003645B2
  申请人：——

  公开号：US8003645B2

  公开（公告）日：2011-08-23