(E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)benzene-1,4-diol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)benzene-1,4-diol
• 英文别名: 2-[(E)-(1,3-benzothiazol-2-ylhydrazinylidene)methyl]benzene-1,4-diol
• 化学式: C₁₄H₁₁N₃O₂S
• 分子量: 285.326
• InChiKey: HOFBQZUCMJCWAR-OVCLIPMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,5-二羟基苯甲醛 、 2-肼基苯并噻唑 以 乙醇 为溶剂， 反应 4.0h， 生成 (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)benzene-1,4-diol
  参考文献：
  名称：

  2-苯并噻唑腙衍生物的超分子固态结构、势能面及体外抗增殖作用评价

  摘要：

  2-肼基苯并噻唑与水杨醛、3,4-二羟基苯甲醛、2,4-二羟基苯甲醛、2,5-二羟基苯甲醛、2,3-二羟基苯甲醛、2-羟基-1-萘甲醛、2-甲氧基-1-的原位缩合反应萘醛、4-甲氧基-1-萘醛和6-甲氧基-2-萘醛产生9 种腙席夫碱（分别为L1-L9），通过元素分析、IR 和NMR 光谱对其进行鉴定和表征。四种席夫碱（L1、L7-L9）的晶体和分子结构已通过单晶 X 射线衍射法确定，证实了 L1 的亚氨基形式和 L7-L9 化合物的氨基互变异构形式。分子结构分析还证实，报告的化合物是 E 异构体，相对于 exo C = N 亚氨基键。氨基互变异构体的Nhydrazino-H基团形成Nhydrazino-H···Nthiazolyl分子间氢键使分子形成R22(8)环，而L1的亚氨基互变异构体通过Nthiazolyl-H···Nhydrazino型形成C(4)无限螺旋链分子间氢键。甲氧基（L7

  DOI：

  10.1007/s11224-016-0856-0

文献信息

• Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones
  作者：Eric B. Lindgren、Monique A. de Brito、Thatyana R.A. Vasconcelos、Manuel O. de Moraes、Raquel C. Montenegro、Julliane D. Yoneda、Kátia Z. Leal

  DOI：10.1016/j.ejmech.2014.08.039

  日期：2014.10

  Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design. (c) 2014 Elsevier Masson SAS. All rights reserved.
• INTERMEDIATE FOR MANUFACTURE OF POLYMERIZABLE COMPOUND AND PROCESS FOR MANUFACTURE THEREOF
  申请人：Sakamoto Kei

  公开号：US20140235857A1

  公开（公告）日：2014-08-21

  The present invention pertains to a compound represented by a formula (I) and a method for producing thereof (in the formula, A x is an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, A y is a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group having 2 to 18 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, or the like. A x and A y optionally bond to each other to form a ring, and Q is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like.). According to the invention, provided are a novel compound that makes it possible to produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band can be inexpensively produced in high yield by utilizing the compound according to one aspect of the invention as an intermediate for producing the polymerizable compound, and a method for producing thereof.
• COPOLYMER, OPTICALLY ANISOTROPIC SUBSTANCE, AND ORIENTED POLYMER FILM
  申请人：ZEON CORPORATION

  公开号：US20150232625A1

  公开（公告）日：2015-08-20

  The present invention relates to: a copolymer comprising repeating units (I) and (II) in its molecule, wherein the content of the repeating units (I) and (II) are 5 to 90 mol % and 95 to 10 mol %, respectively, and a 0.5 g/dl methylene chloride solution of the copolymer having a reduced viscosity (ηsp/c) at 20° C. of 0.3 to 2.0 dl/g; an optically anisotropic article comprising one type or two or more types of the copolymer, or a mixture that includes one type or two or more types of the copolymer, and an additional polymer; and an oriented polymer film obtained by stretching the film-like optically anisotropic article.
• US9207362B2
  申请人：——

  公开号：US9207362B2

  公开（公告）日：2015-12-08
• US9447059B2
  申请人：——

  公开号：US9447059B2

  公开（公告）日：2016-09-20