tetraethyl 2-(diethoxythiophosphonyl)ethane-1,1-bis(phosphonate)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: tetraethyl 2-(diethoxythiophosphonyl)ethane-1,1-bis(phosphonate)
• 英文别名: 2,2-Bis[diethoxy(oxido)phosphaniumyl]ethyl-diethoxy-sulfidophosphanium；2,2-bis[diethoxy(oxido)phosphaniumyl]ethyl-diethoxy-sulfidophosphanium
• 化学式: C₁₄H₃₃O₈P₃S
• 分子量: 454.399
• InChiKey: IKESCJVINFDCPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  O,O'-diethyl thiophosphonate 、 1,1-双(二乙氧基磷酰基)乙烯 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以75%的产率得到tetraethyl 2-(diethoxythiophosphonyl)ethane-1,1-bis(phosphonate)
  参考文献：
  名称：

  Michael addition of phosphorus derivatives on tetraethyl ethylidenediphosphonate

  摘要：

  Nucleophilic phosphorus add to tetraethyl ethylidene diphosphonate in protic solvent to yield the product of the Michael reaction. This reaction appeared to be reversible at a temperature upper than 160 degrees C. To avoid this reverse reaction, alkylation in g. position of the two phosphonate functions by activated elecrophile is reported. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.04.045

文献信息

• Michael addition of phosphorus derivatives on tetraethyl ethylidenediphosphonate
  作者：Lise Delain-Bioton、Adele Turner、Nicolas Lejeune、Didier Villemin、Gary B. Hix、Paul-Alain Jaffrès

  DOI：10.1016/j.tet.2005.04.045

  日期：2005.7

  Nucleophilic phosphorus add to tetraethyl ethylidene diphosphonate in protic solvent to yield the product of the Michael reaction. This reaction appeared to be reversible at a temperature upper than 160 degrees C. To avoid this reverse reaction, alkylation in g. position of the two phosphonate functions by activated elecrophile is reported. (c) 2005 Elsevier Ltd. All rights reserved.