disodium;(3E)-5-[(4-methylphenyl)sulfonylamino]-4-oxo-3-(phenylhydrazinylidene)naphthalene-2,7-disulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: disodium;(3E)-5-[(4-methylphenyl)sulfonylamino]-4-oxo-3-(phenylhydrazinylidene)naphthalene-2,7-disulfonate
• 化学式: C23H17N3Na2O9S3
• 分子量: 621.6
• InChiKey: IXUKHOABHKEJGO-PJXKUKQXSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.74
• 重原子数：
  40
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  227
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Methods for coating surfaces with antimicrobial agents
  申请人：The Board of Regents of the University of Texas System

  公开号：US10589003B2

  公开（公告）日：2020-03-17

  Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the surface with a composition that includes an antimicrobial agent and a solvent, and curing the surface by applying heat. Also disclosed are methods for reducing the risk of development or progression of an infection in a subject in need of a medical device, that involve coating or impregnating a surface of the medical device with an antimicrobial agent and then curing the surface by applying heat, wherein the risk of development or progression of an infection is reduced.

  本发明公开了用抗菌剂涂覆或浸渍表面的方法，包括用包括抗菌剂和溶剂的组合物接触表面，并通过加热固化表面。还公开了降低需要使用医疗器械的受试者发生或恶化感染风险的方法，包括用抗菌剂涂覆或浸渍医疗器械表面，然后通过加热固化表面，从而降低发生或恶化感染的风险。
• Use of a fluorescent protein for detecting interaction between a target protein and its ligand
  申请人：Galzi Jean-Luc

  公开号：US20050059036A1

  公开（公告）日：2005-03-17

  The invention concerns the use of a fluorescent protein selected in particular among the autofluorescent proteins for detecting the non-covalent interaction between a target protein marked by the fluorescent protein and one of its ligands marked by a marker consisting of: either a molecule capable of absorbing the light emitted by the fluorescent protein, or a fluorescent substance, said detection taking place by fluorescence energy transfer: between the fluorescent protein and said fluorescent substance, the fluorescent substance being such that it is excitable at the fluorescent protein emitting wavelength, or it emits at the fluorescent protein emitting wavelength; between the fluorescent protein and said molecule capable of absorbing the light emitted by the fluorescent protein.

  本发明涉及使用一种荧光蛋白，尤其是自发荧光蛋白，用于检测荧光蛋白标记的目标蛋白与其配体之间的非共价相互作用，配体标记包括：能够吸收荧光蛋白发出的光的分子或荧光物质，所述检测通过荧光能量转移进行：荧光蛋白和所述荧光物质之间，荧光物质在荧光蛋白发光波长下可激发，或在荧光蛋白发光波长下发光；荧光蛋白和所述能够吸收荧光蛋白发光的分子之间。
• Method for isolating an allosteric effector of a receptor
  申请人：Galzi Jean-Luc

  公开号：US20060194259A1

  公开（公告）日：2006-08-31

  A method for isolating an allosteric effector of a receptor, by determining the variation of the dissociation kinetics of the complex formed between the receptor and one of its ligands in the presence of the allosteric effector, as compared to the kinetics dissociation, in the absence of the effector, and/or the amplitude of the linkage formed between the receptor and the ligand in the presence of the allosteric effector, as compared to the amplitude in the absence of the effector. The receptor and ligand are being involved in at least one biological response, and the allosteric effector is capable of modulating at least one of the responses. The receptor is marked by at least one fluorescent protein, and the ligand by a molecule capable of absorbing light, or by a fluorescent substance.

  一种用于分离受体的异位效应物的方法，其方法是确定在存在异位效应物的情况下，受体与其配体之间形成的复合物的解离动力学与不存在效应物时的解离动力学相比的变化，和/或在存在异位效应物的情况下，受体与配体之间形成的联系的振幅与不存在效应物时的振幅相比的变化。受体和配体正在参与至少一种生物反应，而异源效应物能够调节至少一种反应。受体由至少一种荧光蛋白标记，配体由能够吸收光的分子或荧光物质标记。
• UTILISATION D' UNE PROTEINE FLUORESCENTE POUR LA DETECTION DE L' INTERACTION ENTRE UN RECEPTEUR MEMBRANAIRE ET SON LIGAND
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP0986759B1

  公开（公告）日：2006-04-26
• UTILISATION D'UNE PROTEINE FLUORESCENTE POUR LA DETECTION D'INTERACTIONS ENTRE UNE PROTEINE CIBLE ET SON LIGAND
  申请人：CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP0986759A2

  公开（公告）日：2000-03-22