2,2'-(1,3-phenylenediethylidyne)bis(hydrazinecarboximidamide)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-(1,3-phenylenediethylidyne)bis(hydrazinecarboximidamide)
• 英文别名: 1-[(E)-1-[3-[(E)-N-guanidino-C-methyl-carbonimidoyl]phenyl]ethylideneamino]guanidine；2-[(E)-1-[3-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]ethylideneamino]guanidine
• 化学式: C₁₂H₁₈N₈
• 分子量: 274.329
• InChiKey: OEBLRFIWEVKLAD-ZEELXFFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• [EN] AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES<br/>[FR] HYDRAZONES D'AMINOGUANIDINE EN TANT QUE STABILISATEURS RÉTROMÈRES UTILES POUR LE TRAITEMENT DE MALADIES NEUROLOGIQUES
  申请人：OSPEDALE SAN RAFFAELE SRL

  公开号：WO2020201326A1

  公开（公告）日：2020-10-08

  The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.

  本发明涉及一种新型氨基胍肼酮衍生物，其化学式为（I），可作为逆转体稳定剂，用作神经保护药物。本发明还涉及包含这些化合物的药物组合物，以及它们在治疗和诊断中的用途。
• Anti-malarial compounds, compositions and methods
  申请人：——

  公开号：US20030186993A1

  公开（公告）日：2003-10-02

  The present invention is directed to substituted naphthothiazolium, aromatic guanylhydrazones, and other compounds and compositions with anti-malarial activity useful for the treatment and prophylaxis of malaria. The compounds are provided for the treatment of malaria or the sequelae of malarial infection, for depolymerizing malaria pigment (hemozoin), and for ameliorating the adverse effects of hemozoin on host cells.

  本发明涉及替代萘并噻唑、芳香基胍脲和其他具有抗疟活性的化合物和组合物，适用于治疗和预防疟疾。这些化合物可用于治疗疟疾或疟疾感染的后遗症，用于降解疟原色素（血红素），并用于改善疟原色素对宿主细胞的不良影响。
• BISHYDRAZONE-BASED ANTIFUNGAL AGENTS
  申请人：University of Kentucky Research Foundation

  公开号：US20180009741A1

  公开（公告）日：2018-01-11

  Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.

  本发明公开了具有抗真菌活性的腙类化合物和包括它们的制药组合物。这些化合物通过给予来治疗或预防需要治疗的受体中的真菌病情。
• Bishydrazone-based antifungal agents
  申请人：University of Kentucky Research Foundation

  公开号：US10173968B2

  公开（公告）日：2019-01-08

  Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.

  公开了具有抗真菌活性的腙化合物和包括腙化合物的药物组合物。此类化合物可用于治疗或预防有需要的受试者的真菌病症。
• AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES
  申请人：OSPEDALE SAN RAFFAELE SRL

  公开号：US20220213030A1

  公开（公告）日：2022-07-07

  The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.