N,4'-dimethyl-[1,1'-biphenyl]-4-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,4'-dimethyl-[1,1'-biphenyl]-4-amine
• 英文别名: N,4'-Dimethyl[1,1'-biphenyl]-4-amine；N-methyl-4-(4-methylphenyl)aniline
• 化学式: C₁₄H₁₅N
• 分子量: 197.28
• InChiKey: VOVJEXLDAMDFBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,4'-dimethyl-[1,1'-biphenyl]-4-amine 生成 2-chloro-N-[methyl-[4-(4-methylphenyl)phenyl]carbamoyl]benzamide
  参考文献：
  名称：

  XAGA, TAKAXIRO;DOKI, TADAAKI;KOYANAGI, TORU;FUDZII, YASUXIRO;JOSIDA, KIEM+

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基联苯 、 N-methyl-O-tosylhydroxylamine 在 air 作用下， 反应 120.0h， 以64%的产率得到N,4'-dimethyl-[1,1'-biphenyl]-4-amine
  参考文献：
  名称：

  无金属直接芳烃 C−H 胺化

  摘要：

  通过形成 CN 键合成芳胺是制备功能材料、活性药物成分和生物活性产品的重要工具。通常，这种化学连接只能通过过渡金属催化的反应、光化学或电化学来实现。在这里，我们报告了在良性条件下使用羟胺衍生物进行的无金属芳烃 C-H 胺化。即使在存在各种官能团的情况下，胺化试剂 TsONHR 和芳烃底物之间的电荷转移相互作用也能实现芳烃的化学选择性胺化。氧气对于有效转化至关重要，其对电子转移步骤的加速作用已通过实验证明。此外，

  DOI：

  10.1002/adsc.202100236

文献信息

• MELANIN PRODUCTION INHIBITOR
  申请人：Yokoyama Kouji

  公开号：US20110243865A1

  公开（公告）日：2011-10-06

  Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C 1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to the number of X's and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

  披露了一种黑色素生产抑制剂，它对黑色素的生产具有出色的抑制活性且高度安全。该黑色素生产抑制剂包括由通用公式（1）表示的化合物（不包括克霉唑）和/或其药理上可接受的盐。在公式中，A1、A2和A3独立地选自氢原子、可能带有取代基的芳基团和可能带有取代基的芳香杂环团，其中至少A1、A2和A3之一选自芳基团和芳香杂环团，A1、A2和A3中包含的碳原子总数为6至50，并且当至少两个A1、A2和A3表示芳基团或芳香杂环团时，相邻的两个芳基或芳香杂环团可以通过烷基链或烯基链相互连接形成环；m代表0至2的整数；X代表异原子、氢原子或碳原子；R1和R2独立地选自氢原子和氧代基，其中当R1和R2之一是氧代基时，另一个不出现；R3选自氢原子和C 1-8 碳氢化合物组，其中一些或所有的氢原子或碳原子可能被异原子或异原子取代，其中化合物中存在的R3的数量对应于X的数量，并且当存在两个或更多R3时，R3独立地存在，并且相邻的两个R3可以相互连接以与X一起形成环，并且R3的末端可以与A1、A2和A3连接的碳原子结合，从而形成环。
• Combination of MTP inhibitors or apoB-secretion inhibitors with fibrates for use as pharmaceuticals
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US20030162788A1

  公开（公告）日：2003-08-28

  The invention relates to the use of fibrates for lowering the liver toxicity of MTP inhibitors as well as pharmaceutical compositions containing an MTP inhibitor and a fibrate.

  本发明涉及使用纤维酸衍生物来降低MTP抑制剂对肝脏的毒性，以及包含MTP抑制剂和纤维酸衍生物的药物组合物。
• Heteroarylcarboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US20030073836A1

  公开（公告）日：2003-04-17

  A compound of formula 1 wherein: A a , R a , X 1 to X 4 , Het, and R 5 to R 7 are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

  根据权利要求1中定义的Aa、Ra、X1至X4、Het和R5至R7，本发明的化合物公式1包括这些化合物的同分异构体和盐，尤其是具有生理活性的盐，它们是微囊体甘油三酯转移蛋白（MTP）的有效抑制剂，含有这些化合物的药物及其用途，以及这些化合物的制备方法。
• Reaction of phenylhydrazines with arenes in the presence of aluminium trichloride
  作者：Atsushi Ohwada、Shigeru Nara、Takeshi Sakamoto、Yasuo Kikugawa

  DOI：10.1039/b103802h

  日期：2001.11.15

  Phenylnitrenium ions are generated from phenylhydrazines by treatment with AlCl3. Reaction of a phenylnitrenium ion with arenes results in both aromatic N-substitution and C-substitution. In contrast, an N-methylphenylnitrenium ion undergoes exclusively aromatic C-substitution. Reaction of a phenylnitrenium ion with arenes present only in slight excess produces anilinated products in moderate to good

  苯基氮离子是由 苯肼通过用AlCl 3处理。苯基硝酸根离子与竞技场 导致同时芳香 N取代和C替代。相反，N-甲基苯基氮鎓离子仅经历芳族C取代。苯基硝酸根离子与竞技场 仅少量过量存在的苯胺产品会以中等到良好的产率产生苯胺化的产品。
• Multicyclic amino acid derivatives and methods of their use
  申请人：Devasagayaraj Arokiasamy

  公开号：US20070191370A1

  公开（公告）日：2007-08-16

  Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:

  公式I和II的化合物已被披露，以及包含它们的组合物和它们的使用方法，用于治疗、预防和管理与血清素介导的疾病和紊乱：