benzyl 2-cyano-5-oxotetrahydrofuran-2-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl 2-cyano-5-oxotetrahydrofuran-2-carboxylate
• 英文别名: Benzyl 2-cyano-5-oxooxolane-2-carboxylate
• 化学式: C₁₃H₁₁NO₄
• 分子量: 245.235
• InChiKey: WBSFBNJIMAYQPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  76.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-chloro-5-oxotetrahydrofuran-2-carboxylic acid benzyl ester 、 cyanotetrabutylammonium 生成 benzyl 2-cyano-5-oxotetrahydrofuran-2-carboxylate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Selective preventives/remedies for progressive lesions after organ damage
  申请人：——

  公开号：US20030181506A1

  公开（公告）日：2003-09-25

  An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.

  本发明的目的是提供一种药物制剂，用于在有机损伤后预防和/或治疗渐进性病变，而不抑制有机功能或再生功能，通过选择性抑制细胞毒性效应巨噬细胞的诱导，这些巨噬细胞是在损伤的器官中受化学因子和细胞因子诱导而表达的，这些化学因子和细胞因子取决于损伤的有机组织的类型。
• SELECTIVE PREVENTIVES/REMEDIES FOR PROGRESSIVE LESIONS AFTER ORGAN DAMAGE
  申请人：Ishibashi, Michio

  公开号：EP1277747A1

  公开（公告）日：2003-01-22

  An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.

  本发明的目的是提供一种药剂，通过选择性地抑制细胞毒性效应巨噬细胞的诱导，预防和/或治疗机体损伤后的进行性病变，而不抑制机体功能或其再生功能。
• Selective preventing and therapeutic agents for progressive lesion after organic damage
  申请人：Ishibashi Michio

  公开号：US20050143453A1

  公开（公告）日：2005-06-30

  An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.

  本发明的目的是提供一种药剂，通过选择性地抑制细胞毒性效应巨噬细胞的诱导，预防和/或治疗机体损伤后的进行性病变，而不抑制机体功能或其再生功能。
• US6878745B2
  申请人：——

  公开号：US6878745B2

  公开（公告）日：2005-04-12