[7-(Dimethylamino)-9,9-dimethylanthracen-2-ylidene]-dimethylazanium

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: [7-(Dimethylamino)-9,9-dimethylanthracen-2-ylidene]-dimethylazanium
• 化学式: C20H25N2+
• 分子量: 293.4
• InChiKey: FNCBNSJJNKQCGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  6.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• SUPER-RESOLUTION FLUORESCENT IMAGING PROBE
  申请人：The University of Tokyo

  公开号：US20180052109A1

  公开（公告）日：2018-02-22

  [Problem] To provide a novel fluorescent probe for super-resolution imaging that uses fluorescent light emission characteristics that originate from an intermolecular nucleophilic addition-dissociation equilibrium reaction, and to provide a super-resolution fluorescent imaging method that uses the probe. [Solution] A fluorescent probe for super-resolution imaging that comprises a compound represented by formula (I) or a salt thereof(in the formula, X represents an oxygen atom, C(R a ) (R b ), or Si(R a ) (R b ) (wherein R a and R b each independently represent a hydrogen atom or an alkyl group), R 1 represents a hydrogen atom or an optionally substituted aryl (provided that, if R 1 is a phenyl group, the benzene ring of the phenyl group does not have a substituent at position 2 or position 6), R 2 and R 3 each independently represent 1-3 identical or differing substituents that are independently selected from the group that consists of hydrogen atoms, hydroxyl groups, halogen atoms, optionally substituted alkyl groups, optionally substituted sulfo groups, optionally substituted carboxyl groups, optionally substituted ester groups, optionally substituted amide groups, and optionally substituted azide groups, R 4 and R 5 each independently represent a hydrogen atom or an optionally substituted alkyl group or N(R 4 ) (R 5 ) forms an amide group or a carbamate group (provided that, if R 4 or R 5 is an alkyl group, each may form, together with R 2 , a ring structure that contains the nitrogen atom that is bonded thereto), and R 6 and R 7 each independently represent a hydrogen atom or an optionally substituted alkyl group or N(R 6 )(R 7 ) forms an amide group or a carbamate group (provided that, if R 6 or R 7 is an alkyl group, each may form, together with R 3 , a ring structure that contains the nitrogen atom that is bonded thereto)), the fluorescent probe for super-resolution imaging being characterized in that the compound represented by formula (I) or the salt thereof undergoes a nucleophilic addition-dissociation equilibrium reaction with a nucleophilic compound that contains an —SH group.

  提供一种新颖的荧光探针，用于超分辨率成像，利用源自分子间亲核加成-解离平衡反应的荧光发射特性，并提供使用该探针的超分辨率荧光成像方法。超分辨率成像的荧光探针包括由式(I)表示的化合物或其盐（在该式中，X代表氧原子，C（Ra）（Rb）或Si（Ra）（Rb）（其中Ra和Rb各自独立表示氢原子或烷基），R1表示氢原子或可选择取代的芳基（前提是，如果R1是苯基，则苯基的苯环在2位或6位不具有取代基），R2和R3各自独立表示1-3个相同或不同的取代基，可从由氢原子、羟基、卤原子、可选择取代的烷基、可选择取代的磺基、可选择取代的羧基、可选择取代的酯基、可选择取代的酰胺基和可选择取代的叠氮基组成的基团中独立选择，R4和R5各自独立表示氢原子或可选择取代的烷基或N（R4）（R5）形成酰胺基或羰酸酯基（前提是，如果R4或R5是烷基，则每个可与R2一起形成含有与其结合的氮原子的环结构），R6和R7各自独立表示氢原子或可选择取代的烷基或N（R6）（R7）形成酰胺基或羰酸酯基（前提是，如果R6或R7是烷基，则每个可与R3一起形成含有与其结合的氮原子的环结构）。超分辨率成像的荧光探针的特征在于，由式(I)表示的化合物或其盐与含有—SH基团的亲核化合物发生亲核加成-解离平衡反应。
• Use of a colorant in order to improve signal detection in an analysis method
  申请人：BIO-RAD EUROPE GMBH

  公开号：US10564156B2

  公开（公告）日：2020-02-18

  The use of at least one colorant is provided in order to improve the detection of a signal corresponding to the presence of an analyte in a dot analysis method, in particular when the detection of the signal takes place in the presence of a liquid phase. Also provided is a dot analysis method that can be used to improve the detection of a signal corresponding to the presence of an analyte, in the presence of a liquid phase containing at least one colorant.

  本发明提供了至少一种着色剂的使用方法，以改进点分析方法中与分析物的存在相对应的信号的检测，特别是当信号的检测是在液相存在的情况下进行时。本发明还提供了一种点分析方法，该方法可用于在含有至少一种着色剂的液相存在的情况下，改进与被分析物的存在相对应的信号的检测。
• Control marker for implementing analysis methods on spots
  申请人：BIO-RAD EUROPE GMBH

  公开号：US10921318B2

  公开（公告）日：2021-02-16

  The present invention relates to the use of a control marker for implementing analysis methods on spots, in particular in the context of multiplex analyses. The present invention thus relates to solid supports containing said control marker, their preparation method and their use in analysis methods. The present invention makes it possible to verify the presence, location and/or integrity of the spots at the end of the analysis method, and thus to secure the obtained results while guaranteeing that the yielded result indeed results from a present, intact and localized spot.

  本发明涉及使用对照标记物在斑点上实施分析方法，特别是在多重分析中。因此，本发明涉及含有所述控制标记的固体支持物、其制备方法及其在分析方法中的使用。本发明可以在分析方法结束时验证斑点的存在、位置和/或完整性，从而确保所获得的结果，同时保证所产生的结果确实来自于一个存在的、完整的和定位的斑点。
• Use of triarylmethane derivatives as direct dyes in a dye composition, composition and implementation process
  申请人：Lagrange Alain

  公开号：US20060021161A1

  公开（公告）日：2006-02-02

  The present patent application relates to the use of triarylmethane derivatives as direct dyes in a dye composition for keratin fibres, in particular human keratin fibres such as the hair, or for the manufacture of such compositions. The present patent application also relates to a dye composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising, in a suitable dyeing medium, at least one particular triarylmethane-based direct dye. The present patent application also relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, using the dye composition according to the invention.

  本专利申请涉及将三芳基甲烷衍生物作为直接染料用于角蛋白纤维，特别是人类角蛋白纤维（如头发）的染色组合物中，或用于制造此类组合物。本专利申请还涉及一种用于染色角蛋白纤维，特别是人类角蛋白纤维（如头发）的染料组合物，该组合物在合适的染色介质中包含至少一种特定的三芳基甲烷直接染料。本专利申请还涉及一种使用本发明染料组合物对角蛋白纤维，特别是人类角蛋白纤维（如头发）进行染色的工艺。
• UTILISATION DE PARTICULES ABSORBANTES POUR AMÉLIORER LA DÉTECTION DU SIGNAL DANS UN PROCÉDÉ D'ANALYSE
  申请人：Bio-Rad Europe GmbH

  公开号：EP3129783B1

  公开（公告）日：2021-06-02