4-[N-(1H-imidazol-1-yl)-N-(3,4-difluorophenylmethyl)amino]benzonitrile | 690248-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[N-(1H-imidazol-1-yl)-N-(3,4-difluorophenylmethyl)amino]benzonitrile
• 英文别名: 4-[(3,4-Difluorophenyl)methyl-imidazol-1-ylamino]benzonitrile
• CAS: 690248-34-1
• 化学式: C₁₇H₁₂F₂N₄
• 分子量: 310.306
• InChiKey: SHGIZOBSVHIUBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors
  申请人：LABORATOIRE THERAMEX

  公开号：EP1431292A1

  公开（公告）日：2004-06-23

  The present invention relates to imidazole derivatives of the formula: in which R1, R2, R3, R4, R5, R6 and n are as defined in the specification. The invention also relates to pharmaceutical compositions containing these derivatives, and to the uses thereof.

  本发明涉及以下式子的咪唑衍生物：其中R1、R2、R3、R4、R5、R6和n的定义如规范中所述。本发明还涉及含有这些衍生物的药物组合物及其用途。
• 1-N-PHENYLAMINO-1H-IMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS
  申请人：LABORATOIRE THERAMEX

  公开号：EP1572665A2

  公开（公告）日：2005-09-14
• US6737433B1
  申请人：——

  公开号：US6737433B1

  公开（公告）日：2004-05-18
• [EN] 1-N-PHENYLAMINO-1H-IMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS<br/>[FR] DERIVES DE 1-N-PHENYLAMINO-1H-IMIDAZOLE ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES DERIVES
  申请人：THERAMEX

  公开号：WO2004054983A2

  公开（公告）日：2004-07-01

  The present invention relates to imidazole derivatives of the formula: (I) in which R1, R2, R3, R4, R5, R6 and n are as defined in the specification.The invention also relates to pharmaceutical compositions containing these derivatives, and to the uses thereof.