N-(4-chlorophenyl)-3-[2-(3-chlorophenyl)ethyl]pyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chlorophenyl)-3-[2-(3-chlorophenyl)ethyl]pyridine-2-carboxamide
• 化学式: C₂₀H₁₆Cl₂N₂O
• 分子量: 371.3
• InChiKey: CIQOCFFPHDXULK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Synthesis of intermediates useful in preparing tricyclic compounds
  申请人：——

  公开号：US20020077331A1

  公开（公告）日：2002-06-20

  Disclosed is a process for preparing a compound having the formula: 1 wherein R, R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy.

  公开了一种制备具有以下式子的化合物的方法：1其中R、R1、R2、R3和R4独立地选自H、Br、Cl、F、烷基或烷氧基的组。
• PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY
  申请人：SCHERING CORPORATION

  公开号：EP1140899B1

  公开（公告）日：2003-09-10
• SYNTHESIS OF INTERMEDIATES USEFUL IN PREPARING TRICYCLIC COMPOUNDS
  申请人：SCHERING CORPORATION

  公开号：EP1131296A2

  公开（公告）日：2001-09-12
• PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO (5,6)-CYCLOHEPTA-(1,2B) -PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE)
  申请人：CANNATA Vincenzo

  公开号：US20090005567A1

  公开（公告）日：2009-01-01

  A process and new oxazolinic intermediates for the preparation of 4-(8-chloro-5,6-dihydro-11H-benzo-[5,6]-clohepta-[1,2-b]-pyridin-11-ylide-ne)-1-piperidinecarboxylic acid ethyl ester (loratadine) is described. The process starts from 2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-3-methyl-pyridine, a new intermediate to obtain loratadine. 2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-3-methyl-pyridine is condensed with 3-chloro-benzyl-chloride and the resultant product is treated with Grignard reagent of 4-chloro-N-methyl-piperidine. [3-(2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl-]-1-(methyl-piperidin-4-yl)-methanone is obtained for subsequent hydrolysis. Starting from this last compound it is possible to obtain loratadine with known methods.
• US6271378B1
  申请人：——

  公开号：US6271378B1

  公开（公告）日：2001-08-07