3-(1,3-benzothiazol-2-ylsulfanyl)-N-(3-methylphenyl)propane-1-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(1,3-benzothiazol-2-ylsulfanyl)-N-(3-methylphenyl)propane-1-sulfonamide
• 化学式: C₁₇H₁₈N₂O₂S₃
• 分子量: 378.5
• InChiKey: DBABHRPCSFRCRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Modulators of Rho C activity
  申请人：——

  公开号：US20030176474A1

  公开（公告）日：2003-09-18

  Compounds of formula 1 modulate the activity of Rho C: 1 wherein n is 2 to 5, inclusive; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are each independently halo, lower alkyl, lower alkoxy, lower alkylamino, trifluoromethyl, nitro, lower alkylthio, or two adjacent residues form cycloalkyl, cycloalkenyl, aryl, or lower alkylenedioxy; and pharmaceutically acceptable salts thereof.
• US6642263B2
  申请人：——

  公开号：US6642263B2

  公开（公告）日：2003-11-04
• [EN] MODULATORS OF RHO C ACTIVITY<br/>[FR] MODULATEURS DE L'ACTIVITE DE RHO C
  申请人：ICONIX PHARM INC

  公开号：WO2003043577A2

  公开（公告）日：2003-05-30

  Compounds of formula (1) modulate the activity of Rho C, wherein n is 2 to 5, inclusive; R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently halo, lower alkyl, lower alkoxy, lower alkylamino, trifluoromethyl, nitro, lower alkylthio, or two adjacent residues form cycloalkyl, cycloalkenyl, aryl, or lower alkylenedioxy; and pharmaceutically acceptable salts thereof.