N-{3,5-dichloro-4-[3-(cyclobutyl-methyl-carbamoyl)-4-hydroxy-phenoxy]-phenyl}-oxamic acid | 1027922-39-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{3,5-dichloro-4-[3-(cyclobutyl-methyl-carbamoyl)-4-hydroxy-phenoxy]-phenyl}-oxamic acid
• 英文别名: 2-[3,5-Dichloro-4-[3-(cyclobutylmethylcarbamoyl)-4-hydroxyphenoxy]anilino]-2-oxoacetic acid
• CAS: 1027922-39-9
• 化学式: C₂₀H₁₈Cl₂N₂O₆
• 分子量: 453.279
• InChiKey: OBPBLKAMBOCSBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Oxamic acids and derivatives as thyroid receptor ligands
  申请人：——

  公开号：US20030114521A1

  公开（公告）日：2003-06-19

  The present invention provides novel compounds of the Formula 1 and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R 1 —R 8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, glaucoma, cardiac arrhythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.

  本发明提供了式1的新化合物及其前药、几何和光学异构体以及这些化合物、前药和异构体的药学上可接受的盐，其中R1-R8和W如本文所述。还提供了含有这些化合物、前药、异构体或其药学上可接受的盐的药物组合物，以及用于治疗肥胖症、高脂血症、青光眼、心律失常、皮肤疾病、甲状腺疾病、甲状腺功能减退症以及相关的疾病和疾病，如糖尿病、动脉硬化、高血压、冠心病、高胆固醇血症、抑郁症和骨质疏松症的方法、药物组合物和工具包。
• Medical use of thyromimetic compounds to treat hair loss and compositions
  申请人：Pfizer Products Inc.

  公开号：EP1262177A2

  公开（公告）日：2002-12-04

  The present invention provides methods and compositions for treating hair loss, including arresting and/or reversing hair loss and/or promoting hair growth, in mammals, such as humans, companion animals and livestock, using certain thyromimetic compounds.

  本发明提供了利用某些拟甲状腺化合物治疗哺乳动物（如人类、伴侣动物和家畜）脱发的方法和组合物，包括阻止和/或逆转脱发和/或促进毛发生长。
• Method of treating hair loss using thyromimetic compounds
  申请人：——

  公开号：US20030007941A1

  公开（公告）日：2003-01-09

  The present invention provides methods and compositions for treating hair loss, including arresting and/or reversing hair loss and/or promoting hair growth, in mammals, such as humans, companion animals and livestock, using certain thyromimetic compounds.

  本发明提供了利用某些拟甲状腺化合物治疗哺乳动物（如人类、伴侣动物和家畜）脱发的方法和组合物，包括阻止和/或逆转脱发和/或促进毛发生长。
• OXAMIC ACIDS AND DERIVATIVES AS THYROID RECEPTOR LIGANDS
  申请人：Pfizer Products Inc.

  公开号：EP1157001A1

  公开（公告）日：2001-11-28
• PEPTIDES THAT BIND TO ATHEROSCLEROTIC LESIONS
  申请人：Novartis AG

  公开号：EP1419173A2

  公开（公告）日：2004-05-19