(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethylsulfanyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethylsulfanyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 化学式: C₁₅H₁₇N₅O₆S₃
• 分子量: 459.5
• InChiKey: YOPGQIJFFQMKGU-HBWVYFAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  235
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• Novel c-3 s/o-and s/n formaldehe acetal derivatives of cephalosporins and their use as antibotics
  申请人：——

  公开号：US20040260084A1

  公开（公告）日：2004-12-23

  The compounds of the general formula (I) wherein R 1 denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R 2 denotes a pharmaceutically acceptable group which is bonded to the remaining part of the molecule by an oxygen-carbon single bond or a nitrogen-carbon single bond, and their pharmaceutically acceptable salts, esters and amide derivatives are effective antibiotics. 1

  通式（I）的化合物，其中R1表示在头孢菌素领域中惯常使用的药用可接受的侧链基团，而R2表示通过氧-碳单键或氮-碳单键与分子的其余部分连接的药用可接受的基团，以及它们的药用可接受的盐、酯和酰胺衍生物是有效的抗生素。
• NOVEL C-3 S/O- AND S/N FORMALDEHE ACETAL DERIVATIVES OF CEPHALO SPORINS AND THEIR USE AS ANTIBIOTICS
  申请人：Pfaendler, Hans Rudolf

  公开号：EP1444237A1

  公开（公告）日：2004-08-11
• [EN] NOVEL C-3 S/O- AND S/N FORMALDEHE ACETAL DERIVATIVES OF CEPHALO SPORINS AND THEIR USE AS ANTIBIOTICS<br/>[FR] NOUVEAUX DERIVES ACETAL DE FORMALDEHYDE C-3 S/O- ET S/N DE CEPHALOSPORINES ET LEUR UTILISATION EN TANT QU'ANTIBIOTIQUES
  申请人：PFAENDLER HANS RUDOLF

  公开号：WO2003042219A1

  公开（公告）日：2003-05-22

  The compounds of the general formula (I) wherein R1 denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R2 denotes a pharmaceutically acceptable group which is bonded to the remaining part of the molecule by an oxygen-carbon single bond or a nitrogen-carbon single bond, and their pharmaceutically acceptable salts, esters and amide derivatives are effective antibiotics.