6-[7-(3-benzyl-ureido)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-3-phenyl-hexanoic acid | 320385-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[7-(3-benzyl-ureido)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-3-phenyl-hexanoic acid
• 英文别名: (R,S)-6-[7-(3-benzyl-ureido)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-3-phenyl-hexanoic acid；6-[7-(Benzylcarbamoylamino)-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]-3-phenylhexanoic acid
• CAS: 320385-77-1
• 化学式: C₂₉H₃₀N₄O₅
• 分子量: 514.581
• InChiKey: YDVWDIIPCPHOEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  128
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• US6506744B1
  申请人：——

  公开号：US6506744B1

  公开（公告）日：2003-01-14
• [EN] BENZAZEPINONES AND QUINAZOLINES<br/>[FR] BENZAZEPINONES ET QUINAZOLINES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001004103A1

  公开（公告）日：2001-01-18

  Compounds of formula (I), as well as pharmaceutically usable salts and esters thereof, wherein R1, R2, X, Y, Z and p have the significance given in claim 1, inhibit the binding of adhesive proteins to the surface of different types of cell and accordingly influence cell-cell and cell-matrix interactions. They can be used in the form of pharmaceutical preparations for the treatment or prevention of neoplasms, tumour metastasis, tumour growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, restenosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure as well as infection caused by viruses, bacteria or fungi.