2-(2-methylbut-2-yl)benzo[b]thiophene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-(2-methylbut-2-yl)benzo[b]thiophene
• 英文别名: 2-tert-amylbenzo[b]thiophene；2-(2-Methylbutan-2-yl)-1-benzothiophene
• 化学式: C₁₃H₁₆S
• 分子量: 204.336
• InChiKey: CCZGTQZRUKRSKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯代-2-甲基丁烷 、 苯并噻吩 在 二硫化碳 、 aluminum (III) chloride 作用下， 反应 12.0h， 生成 2-(2-methylbut-2-yl)benzo[b]thiophene
  参考文献：
  名称：

  Formation of Benzo[b]Thiophenes by Electroreduction of Tert-Alkanecarbodithioates

  摘要：

  The electroreduction of a 1:1-mixture of 2-bromobenzyl 2,2-dimethylpropanedithioate and 2-bromo-5-methylbenzyl 2,2-dimethylbutanedithioate led to a mixture of 2-tert-butylbenzo[b]thiophene, 2-tert-amylbenzo[b]thiophene, 2-tert-butyl-5-methylbenzo[b]thiophene and 2-tert-amyl-5-methylbenzo[b]thiophene. The formation of the four different products instead of only the two expected compounds, 2-tert-butylbenzo[b]thiophene and 2-tert-amyl-5-methylbenzo[b]thiophene, which would result from a straightforward reductive cyclization of each dithioester, is indicative of a reaction pathway with cleavage of the intermediates and intermolecular recombination of the fragments.

  DOI：

  10.1080/10426507.2015.1071370

文献信息

• NOVOBIOCIN ANALOGUES AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE
  申请人：Calvet James P.

  公开号：US20110082098A1

  公开（公告）日：2011-04-07

  Novobiocin analogues are useful in methods of treating, inhibiting, and/or preventing cyst formation in autosomal dominant polycystic kidney disease (ADPKD) in a subject. The disclosure provides methods of treating ADPKD comprising administering a therapeutically effective amount of a coumarin-3-carboxamide novobiocin analogue. Accordingly, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of mTOR pathway phosphoproteins P-mTOR, P-Akt and P-S6K, or combinations thereof. Further, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of Hsp-90 client proteins CFTR, ErbB2, c-Raf and Cdk4, or combinations thereof.

  新比奴霉素类似物在治疗、抑制和/或预防自体显性多囊肾病（ADPKD）中的囊肿形成方法中是有用的。本公开提供了治疗ADPKD的方法，包括给予香豆素-3-羧酰胺新比奴霉素类似物的治疗有效量。因此，该方法可以包括给予新比奴霉素类似物的治疗有效量，以降低mTOR途径磷酸化蛋白P-mTOR、P-Akt和P-S6K的水平，或其组合。此外，该方法可以包括给予新比奴霉素类似物的治疗有效量，以降低Hsp-90客体蛋白CFTR、ErbB2、c-Raf和Cdk4的水平，或其组合。
• Macrocyclic hepatitis C serine protease inhibitors
  申请人：Ku Yiyin

  公开号：US20100144608A1

  公开（公告）日：2010-06-10

  The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

  本发明涉及新型大环化合物及其用于治疗需要该治疗的丙型肝炎感染患者的方法。本发明还涉及包含本发明化合物或其药学上可接受的盐、酯或前药与药学上可接受的载体或赋形剂组合的制药组合物。
• Novobiocin Analogues
  申请人：Blagg Brian

  公开号：US20090187014A1

  公开（公告）日：2009-07-23

  Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders, as well as cancer.

  Novobiocin类似物和含有这些化合物的药物组合物，可用于治疗和/或预防神经退行性疾病、自身免疫性疾病以及癌症。
• METHOD OF DESULFURIZING HYDROCARBON OIL
  申请人：JAPAN ENERGY CORPORATION

  公开号：EP1715025A1

  公开（公告）日：2006-10-25

  An object of the present invention is to provide a desulfurizing and refining method for hydrocarbon oil for reducing sulfur compounds to an extremely low concentration at a relatively low equipment cost and operating cost. The method for desulfurizing hydrocarbon oils comprises causing a hydrocarbon oil containing at least one sulfur compound selected from the group consisting of thiophene compounds, benzothiophene compounds, and dibenzothiophene compounds or a hydrocarbon oil further containing aromatic hydrocarbons to come in contact with a solid acid catalyst and/or activated carbon containing a transition metal oxide. The solid acid catalyst is preferably a solid superacid catalyst selected from sulfated zirconia, sulfated alumina, sulfated tin oxide, sulfated iron oxide, tungstated zirconia, and tungstated tin oxide.

  本发明的目的是提供一种碳氢化合物油的脱硫和精炼方法，以相对较低的设备成本和操作成本将硫化合物降低到极低的浓度。 该烃类油脱硫方法包括使含有至少一种选自噻吩化合物、苯并噻吩化合物和二苯并噻吩化合物或进一步含有芳香烃的烃类油的烃类油与固体酸催化剂和/或含有过渡金属氧化物的活性炭接触。固体酸催化剂最好是选自硫酸化氧化锆、硫酸化氧化铝、硫酸化氧化锡、硫酸化氧化铁、钨酸化氧化锆和钨酸化氧化锡的固体超酸催化剂。
• METHOD FOR DESULFURIZATION OF HYDROCARBON OIL
  申请人：Japan Energy Corporation

  公开号：EP1923451A1

  公开（公告）日：2008-05-21

  Disclosed is a method for desulfurization of a hydrocarbon oil (e.g., kerosene which is a raw fuel for a fuel cell) which can effectively remove benzothiophenes and dibenzothiophenes contained in the hydrocarbon oil under mild conditions to produce a desulfurized hydrocarbon oil having a significantly low sulfur content. The method comprises the step of desulfurizing the hydrocarbon oil such as kerosene containing benzothiophenes and dibenzothiophenes with the combination of a solid acid-type desulfurizing agent and an active carbon-type desulfurizing agent. This method can provide a hydrocarbon oil having a significantly low sulfur content. By using the hydrocarbon oil, the operation or maintenance of a fuel cell system can be made easily, a fuel cell itself can be miniaturized in size, and the lifetime of a desulfurizing agent in a desulfurization apparatus equipped in a fuel cell system can be prolonged.

  本发明公开了一种碳氢化合物油（例如作为燃料电池原燃料的煤油）的脱硫方法，该方法可在温和条件下有效去除碳氢化合物油中所含的苯并噻吩和二苯并噻吩，从而生产出硫含量明显较低的脱硫碳氢化合物油。 该方法包括使用固体酸型脱硫剂和活性碳型脱硫剂对含有苯并噻吩和二苯并噻吩的烃类油（如煤油）进行脱硫的步骤。这种方法可以提供一种硫含量明显较低的碳氢化合物油。通过使用这种碳氢化合物油，可以使燃料电池系统的操作或维护变得简单，燃料电池本身的尺寸可以小型化，燃料电池系统中配备的脱硫装置中的脱硫剂的使用寿命可以延长。