5-O-[[1-[[benzyl(methyl)amino]methyl]cyclohexyl]methyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-O-[[1-[[benzyl(methyl)amino]methyl]cyclohexyl]methyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 化学式: C32H39N3O6
• 分子量: 561.7
• InChiKey: QJTOUSNFPMBWHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 1,4-Dihydropyridine derivatives, method for preparing the same and use thereof
  申请人：TEIKOKU CHEMICAL INDUSTRIES CO., LTD.

  公开号：EP0479665A2

  公开（公告）日：1992-04-08

  A compound represented by the formula (I) : where A is a phenyl group substituted at least with a nitro group ; B is a group represented by the formula : [where R1 and R2 are, the same or different, a lower alkyl group or a benzyl group which may be substituted with a halogen atom, or they may be combined, together with the adjacent nitrogen atom, through or not through an oxygen atom to form a six-membered ring or through a nitrogen atom to form a group represented by the formula : (where R3 is a lower alkyl group, a phenyl or benzyl group which may be substituted with a halogen atom, or a diphenylmethyl group)] ; and R is a hydrogen atom or a lower alkyl group ,or a salt thereof. This compound or a salt thereof is effective as an antihypertensive agent.

  由式 (I) 所代表的化合物： 其中 A 是至少被硝基取代的苯基；B 是由式（I）代表的基团： [其中 R1 和 R2 相同或不同，均为低级烷基或苄基，可被卤素原子取代，也可与相邻的氮原子结合，通过或不通过氧原子形成六元环或通过氮原子形成由式......表示的基团： (其中 R3 为低级烷基、可被卤素原子取代的苯基或苄基或二苯基甲基）]；R 为氢原子或低级烷基或其盐。该化合物或其盐可作为有效的降压药。
• JPH05230023A
  申请人：——

  公开号：JPH05230023A

  公开（公告）日：1993-09-07