N-[2-[3-chloro-5-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-1-benzofuran-2-yl]phenyl]-1,1,1-trifluoromethanesulfonamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: N-[2-[3-chloro-5-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-1-benzofuran-2-yl]phenyl]-1,1,1-trifluoromethanesulfonamide
• 化学式: C₂₆H₂₂ClF₃N₄O₃S
• 分子量: 563.0
• InChiKey: OZVAVOGJNRKZMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  98.4
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] ANTIHYPERTENSIVE 5-[(IMIDAZO[4,5-b]PYRIDIN-3-YL)METHYL]BENZOFURAN DERIVATIVES<br/>[FR] DERIVES DU 5-[(IMIDAZO[4,5-b]PYRIDIN-3-YL)METHYL]BENZOFURANNE UTILISES COMME ANTIHYPERTENSEURS
  申请人：GLAXO GROUP LIMITED

  公开号：WO1994011369A1

  公开（公告）日：1994-05-26

  (EN) The invention relates to the compounds: N-[2-[3-chloro-5-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-2-benzofuranyl]phenyl]trifluoromethanesulphonamide; 3-[[3-chloro-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5-benzofuranyl]methyl]-2-ethyl-7-methyl-3H-imidazo[4,5-b]pyridine-5-methanol; N-[2-[3-chloro-5-[[2-ethyl-5-[2-(hydroxypropyl)]-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl]methyl]-2-benzofuranyl]phenyl]trifluoromethanesulphonamide; 3-[[3-chloro-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5-benzofuranyl]methyl]-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridine-5-methanol; N-[2-[3-chloro-5-[[5-[2-(hydroxypropyl)]-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl]methyl]-2-benzofuranyl]phenyl]trifluoromethanesulphonamide; and physiologically acceptable salts and solvates thereof. The invention further relates to processes for their preparation, pharmaceutical compositions containing them, and to their use in medicine, particularly in the treatment of hypertension.(FR) L'invention concerne les composés: N-[2-[3-chloro-5-[(5,7-diméthyl-2-éthyl-3H-imidazo[4,5-b]pyridin-3-yl)méthyl]-2-benzofuranyl]phényl]trifluorométhanesulfonamide; 3-[[3-chloro-2-[2-[[(trifluorométhyl)sulfonyl]amino]phényl]-5-benzofuranyl]méthyl]-2-éthyl-7-méthyl-3H-imidazo[4,5-b]pyridine-5-méthanol; N-[2-[3-chloro-5-[[2-éthyl-5-[2-(hydroxypropyl)]-7-méthyl-3H-imidazo[4,5-b]pyridin-3-yl]méthyl]-2-benzofuranyl]phényl]trifluorométhanesulfonamide; 3-[[3-chloro-2-[2-[[(trifluorométhyl)sulfonyl]amino]phényl]-5-benzofuranyl]méthyl]-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridine-5-méthanol; N-[2-[3-chloro-5-[[5-[2-(hydroxypropyl)]-7-méthyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl]méthyl]-2-benzofuranyl]phényl]trifluorométhanesulfonamide. L'invention concerne également les sels et les solvates de ces dérivés acceptables sur le plan pharmaceutique, ainsi que leur préparation, les compositions pharmaceutiques les contenant et leur utilisation en médecine, en particulier dans le traitement de l'hypertension.