[3-[4-(1-Methyl-6-nitroindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]methyl 3-(diethylaminomethyl)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3-[4-(1-Methyl-6-nitroindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]methyl 3-(diethylaminomethyl)benzoate
• 化学式: C34H31N5O6
• 分子量: 605.6
• InChiKey: KRTTWVXCJHPZEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  45
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  131
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1242408A1

  公开（公告）日：2002-09-25
• US6313143B1
  申请人：——

  公开号：US6313143B1

  公开（公告）日：2001-11-06
• [EN] SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION<br/>[FR] BISINDOLYLMALEIMIDES SUBSTITUES DESTINES A INHIBER LA PROLIFERATION CELLULAIRE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001044234A1

  公开（公告）日：2001-06-21

  Disclosed are novel substituted pyrroles having formula (I). These compounds and their pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion solution and are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds and methods for the treatment and/or control of cancer.