3-[3-(2-bromo-5-fluorophenoxy)-N-[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]anilino]-1,1,1-trifluoropropan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[3-(2-bromo-5-fluorophenoxy)-N-[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]anilino]-1,1,1-trifluoropropan-2-ol
• 化学式: C₂₄H₁₈BrF₈NO₃
• 分子量: 600.3
• InChiKey: MIUPBNYSVRKUMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity
  申请人：——

  公开号：US20020120011A1

  公开（公告）日：2002-08-29

  The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted diamines. A preferred specific N,N-disubstituted diamine is the compound: 1

  这项发明涉及替代多环芳基和杂环芳基的三级杂烷基胺化合物，可用作胆固醇酯转移蛋白（CETP；血浆脂质转移蛋白-I）的抑制剂，以及用于治疗动脉粥样硬化和其他冠状动脉疾病的化合物、组合物和方法。首选的三级杂烷基胺化合物是取代的N,N-二取代二胺。首选的具体N,N-二取代二胺化合物是：1
• [EN] (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(n+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY<br/>[FR] AMINO-(N+1)-ALCANOLS 1-SUBSTITUES HALOGENES R-CHIRAUX, UTILES COMME INHIBITEURS DE L'ACTIVITE DE LA PROTEINE DE TRANSFERT DE L'ESTER DE CHOLESTERYLE
  申请人：MONSANTO CO

  公开号：WO2000018724A1

  公开（公告）日：2000-04-06

  The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.

  本发明涉及取代芳基和杂环芳基(R)-手性卤代1-取代氨基-(n+1)-脂肪醇化合物，用于抑制胆固醇酯转移蛋白(CETP;血浆脂质转移蛋白-I)以及用于治疗动脉硬化和其他冠状动脉疾病的化合物、组合物和方法。本发明还描述了从手性和非手性中间体制备手性取代脂肪醇化合物的新型高产率、立体选择性过程。
• Substituted N, N-disubstituted cycloalkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
  申请人：——

  公开号：US20020165232A1

  公开（公告）日：2002-11-07

  The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.

  本发明涉及取代的多环芳基和杂环芳基三级-杂基烷胺化合物，用于作为胆固醇酯转移蛋白（CETP; 血浆脂质转移蛋白-I）的抑制剂，并涉及用于治疗动脉粥样硬化和其他冠状动脉疾病的化合物、组合物和方法。
• Substituted n-phenyl-n-fused-benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
  申请人：——

  公开号：US20020183397A1

  公开（公告）日：2002-12-05

  The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N-phenyl-N-fused-benzyl aminoalcohols. A preferred specific N-phenyl-N-fused-benzyl aminoalcohol is the compound: 1

  本发明涉及取代的多环芳基和杂环芳基三级-杂代烷基胺化合物，可用作胆固醇酯转移蛋白（CETP;血浆脂质转移蛋白-I）抑制剂，以及用于治疗动脉粥样硬化和其他冠状动脉疾病的化合物、组合物和方法。优选的三级-杂代烷基胺化合物是取代的N-苯基-N-融合苄基氨基醇。一种优选的特定N-苯基-N-融合苄基氨基醇化合物是化合物：1。
• Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
  申请人：G.D. Searle & Co.

  公开号：US20030032644A1

  公开（公告）日：2003-02-13

  Substituted Polycyclic Aryl and Heteroaryl tetiary-leteroalkylamines Useful for Inhibiting Cholesteryl Ester Transfer Protein Activity Abstract The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.

  替代多环芳基和杂环芳基三级叔碳基胺，用于抑制胆固醇酯转移蛋白活性的抑制剂。本发明涉及替代多环芳基和杂环芳基的三级杂碳基胺化合物，用作胆固醇酯转移蛋白（CETP；血浆脂质转移蛋白-I）的抑制剂，以及治疗动脉粥样硬化和其他冠状动脉疾病的化合物、组合物和方法。