2-[(1R,2R,3R,4R)-2-(carboxymethyl)-3,4-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclobutyl]acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(1R,2R,3R,4R)-2-(carboxymethyl)-3,4-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclobutyl]acetic acid
• 化学式: C₄₂H₄₆N₂O₈
• 分子量: 706.8
• InChiKey: UJZCQDJDJYVDCE-BVTGPKHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  52
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE
  申请人：Abbott Laboratories

  公开号：EP0677039A1

  公开（公告）日：1995-10-18
• Skeletal muscle protecting agent
  申请人：Tozawa Ryuichi

  公开号：US20080113965A1

  公开（公告）日：2008-05-15

  The present invention provides a novel drug which is useful as a skeletal muscle protecting agent comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
• REMEDY FOR XANTHOMA
  申请人：Shiomi Masashi

  公开号：US20090082333A1

  公开（公告）日：2009-03-26

  A preventive/remedy for xanthoma which contains a compound having an inhibitory effect on squalene synthase, its prodrug or its salt.
• Crp Lowering Agent
  申请人：Imura Yoshimi

  公开号：US20090118255A1

  公开（公告）日：2009-05-07

  The present invention provides a novel drug which is useful as a preventive and/or therapeutic agent for various diseases involved in elevation of CRP level, in particular, inflammatory disease and cancer comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
• Novel Method of Treating Hyperlipidemia
  申请人：Nishimoto Tomoyuki

  公开号：US20090209510A1

  公开（公告）日：2009-08-20

  A pharmaceutical composition useful for a prevention and/or treatment of hyperlipidemia, which comprises combining an effective amount of squalene synthase inhibitor and HMG-CoA reductase inhibitor is provided.