primycin sulphate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: primycin sulphate
• 英文别名: primycin sulfate；2-[5-[(4E,20E)-35-butyl-19-[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-10,12,14,16,18,22,26,30,34-nonahydroxy-3,5,21,33-tetramethyl-36-oxo-1-oxacyclohexatriaconta-4,20-dien-2-yl]-4-hydroxyhexyl]guanidine;sulfuric acid
• 化学式: C₅₅H₁₀₃N₃O₁₇*H₂O₄S
• 分子量: 1176.51
• InChiKey: WYOUCIQCRSLAPX-FPAXZPBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  80
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  455
• 氢给体数：
  17
• 氢受体数：
  22

文献信息

• Pseudo-primycin complexes, components and acid addition salts thereof as well as a process for the preparation of same
  申请人：CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

  公开号：EP0350430A2

  公开（公告）日：1990-01-10

  The invention relates to antibacterial pseudo-primycin complexes of formula (I) to the components and acid addition salts thereof, as well as to the preparation of these compounds and to the pharmaceutical compositions containing said compounds as active ingredient. In the formula (I) R1 is butyl, pentyl or hexyl, R2 is hydrogen, hydroxyl or O-arabinose and X is organic or inorganic acid ion.

  本发明涉及式（I）的抗菌伪普利霉素复合物 其组分和酸加成盐，以及这些化合物的制备和含有上述化合物作为活性成分的药物组合物。 在式 (I) 中，R1 是丁基、戊基或己基，R2 是氢、羟基或 O-阿拉伯糖，X 是有机或无机酸离子。
• Synergistic pharmaceutical composition with an antimicrobial action and process for preparing same
  申请人：CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

  公开号：EP0351698A1

  公开（公告）日：1990-01-24

  The invention relates to a synergistic antimicrobial pharmaceutical composition as well as to a process for preparing this composition. The composition of the invention contains a primycin antibiotic complex and/or a synergistic combination of the isolated components thereof as well as (a) chemotherapeutic agent(s) and optionally (an) other antibiotic(s) in admixture with filling, diluting and formulating materials commonly used in the pharma­ceutical industry.

  本发明涉及一种协同抗菌药物组合物以及制备这种组合物的工艺。本发明的组合物含有伯氨喹抗生素复合物和/或其分离成分的协同组合物，以及（一种）化疗药物和（一种）其他抗生素，并与制药业常用的填充、稀释和配制材料混合。
• Primycin solutions
  申请人：CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

  公开号：EP0367586A1

  公开（公告）日：1990-05-09

  The invention relates to novel stable aqueous primycin solutions containing 0.5 to 1.75% by mass/volume of primycin sulfate or 2.5 to 9% by mass/volume of a complex of primycin with N-methylpirrolidone and 2 to 15% by mass/volume of pyroglutamic acid, preferably L-­-pyroglutamic acid or a soluble salt, preferably the sodium salt thereof as calculated for the volume of the solution to be prepared and 40 to 600% by volume of isopropanol as calculated for the volume of the solution to be prepared as well as water in an amount supplementing up to 100%. The invention further relates to pharmaceutical or disinfecting cosmetic compositions mainly for topical treatment containing the above primycin solution optionally in admixture with pharmaceutically acceptable auxiliary materials and, if desired. with other non-synergistic therapeutically active ingredient(s), suitably desquamating and/or antiinflammatory agent(s). The invention further relates to the preparation of the above primycin solutions and compositions containing these solutions.

  本发明涉及新型稳定的伯氨霉素水溶液，按质量/体积计，含有 0.5-1.75% 的硫酸伯 氨霉素或 2.本发明涉及新型稳定的伯氨喹水溶液，按质量/体积计算，含有 0.5 至 1.75% 的硫酸伯氨喹或 2.5 至 9% 的伯氨喹与 N-甲基吡咯烷酮的复合物；按质量/体积计算，含有 2 至 15%的焦谷氨酸，最好是 L-焦谷氨酸或其可溶性盐，最好是其钠盐；按质量/体积计算，含有 40 至 600% 的异丙醇，以及补充量达 100%的水。 本发明还涉及主要用于局部治疗的药用或消毒化妆品组合物，该组合物含有上述伯氨喹溶液，可选择与药学上可接受的辅助材料混合，如果需要，还可与其他非协同治疗活性成分混合，适当地与去鳞屑剂和/或消炎剂混合。 本发明还涉及上述伯氨喹溶液和含有这些溶液的组合物的制备。
• Pharmaceutical combinations comprising a fungicide, a bacteriostatic sulphonamide and an antibacterial compound for topical application
  申请人：Lukacs Karoly

  公开号：US20050043222A1

  公开（公告）日：2005-02-24

  Medical combination and its method of topical use comprising active ingredients which are sparingly soluble in water, preferably in one single composition against microbes which are pathogenic in humans and animals and which usually appear together. It comprises at least one active ingredient which is effective against several of the opportunally pathogenic strains of the group consisting of fungi Candida, Aspergillus , and/or Fusarium , and aerobic bacteria: Gram-negative bacilli such as Proteus, Pseudomonas, enterobacter species, Escherichia coli, Klebsiella, Serratia marcescens, Citrobacter, Aeromonas ; Gram-negative cocci such as Neisseria, Acinetobacter species; Gram-positive bacilli such as Corynebacterium speies, Bacillus sphaericus , Gram-positive cocci such as Streptococcus species; anaerobic bacteria: Gram-negative cocci such as Bacteroides, Fusobacteria ; Gram-positive cocci such as Peptococcus, Peptostreptococcus species; Gram-positive bacilli such as Clostridium, Propionibacterium, Eubacterium species and Mycobacterium species suh as Mycobacterium ulcerans , microbes similar to bacteria of the Chlamydia species such as Chlamydia trachomatis . To be used for treatment of the skin or mucous membranes bearing epithelial lesions, deficiency or injuries and to be used in body cavities to prevent or cure infections and deficiencies. The composition contains-dispersed in a carrier which is pharmaceutically acceptable on the site of treatment-at least one fungicide, which is preferably azole or polyene type and at least one antibacterial compound preferably of the erythromycin, azalide, linkozamide, polypeptide type and at least one bacteriostatic sulphonamide. Additionals mainly for use on skin may include zinc oxide and asulene. Useful in forms of ointment, tablet, effervescent tablet, suppository, foam.

  医用复方制剂及其局部使用方法，其有效成分易溶于水，最好为单一成分，可防治通常同时出现在人和动物体内的致病微生物。它包含至少一种活性成分，这种活性成分对真菌类中的几种机会致病菌株有效，包括 念珠菌、曲霉 和/或 镰刀菌 和需氧细菌：革兰氏阴性杆菌，如 变形杆菌、假单胞菌、肠杆菌 菌种、 大肠杆菌、克雷伯氏菌、肉豆蔻沙雷氏菌、柠檬酸杆菌、气单胞菌 革兰氏阴性球菌，如 奈瑟氏菌、醋酸杆菌 革兰氏阳性杆菌，如 革兰氏阳性杆菌，如 芽孢杆菌 芽孢杆菌 革兰氏阳性球菌，如 链球菌 厌氧菌：革兰氏阴性球菌，如 厌氧细菌：革兰氏阴性球菌，如乳酸杆菌、镰刀菌 革兰氏阳性球菌，如 革兰氏阳性球菌，如肽球菌、肽链球菌 革兰氏阳性杆菌，如 梭状芽孢杆菌、丙酸杆菌、优杆菌等革兰氏阳性杆菌 种和 分枝杆菌 种，如 溃疡分枝杆菌 等微生物类似于 衣原体 类细菌相似的微生物，如 沙眼衣原体 .用于治疗皮肤或粘膜上皮病变、缺损或损伤，也可用于体腔内预防或治疗感染和缺损。该组合物包含--分散在治疗部位药学上可接受的载体中--至少一种杀真菌剂，最好是唑类或多烯类；至少一种抗菌化合物，最好是红霉素类、氮芥类、链脲类、多肽类；至少一种抑菌磺酰胺。主要用于皮肤的添加剂可包括氧化锌和asulene。可用软膏、片剂、泡腾片、栓剂、泡沫剂等形式。
• Primycin-salze, Verfahren zur deren Herstellung sowie diese enthaltende pharmazeutische Präparate
  申请人：CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

  公开号：EP0167146B1

  公开（公告）日：1990-10-24