4-acetamido-N-(cyclopropylmethyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-acetamido-N-(cyclopropylmethyl)benzamide
• 化学式: C₁₃H₁₆N₂O₂
• 分子量: 232.28
• InChiKey: DUHQCEIIJAJDGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• METHODS FOR THE TREATMENT OF PAIN AND TRAUMATIC INJURY USING BENZAMIDES AND COMPOSITIONS CONTAINING THE SAME
  申请人：Renovis, Inc.

  公开号：EP1581202A2

  公开（公告）日：2005-10-05
• Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
  申请人：——

  公开号：US20040167226A1

  公开（公告）日：2004-08-26

  Methods are disclosed for treating and preventing pain such as neuropathic pain, and traumatic injuries such as traumatic brain injury and acute spinal cord injury, which comprise administering effective amounts of a benzamide compound of formula I: 1 where n is 1 or 2, R 1 is a group selected from acetyl, alkyl, amino, acylamino (NHCOR 3 ), halo, nitro, and trifluoroalkyl, R 2 is saturated alkyl of 3 to 5 atoms, and R 3 is alkyl of 1 to 5 atoms. Pharmaceutical compositions, dosage forms and methods of administration are set forth.
• [EN] METHODS FOR THE TREATMENT OF PAIN AND TRAUMATIC INJURY USING BENZAMIDES AND COMPOSITIONS CONTAINING THE SAME<br/>[FR] METHODES UTILISANT DES BENZAMIDES ET DES COMPOSITIONS CONTENANT CES BENZAMIDES POUR LE TRAITEMENT DE LA DOULEUR ET DES TRAUMATISMES,
  申请人：RENOVIS INC

  公开号：WO2004060286A2

  公开（公告）日：2004-07-22

  Methods are disclosed for treating and preventing pain such as neuropathic pain, and traumatic injuries such as traumatic brain injury and acute spinal cord injury, which comprise administering effective amounts of a benzamide compound of formula I: (I) where n is 1 or 2, R1 is a group selected from acetyl, alkyl, amino, acylamino (NHCOR3), halo, nitro, and trifluoroalkyl, R2 is saturated alkyl of 3 to 5 atoms, and R3 is alkyl of 1 to 5 atoms. Pharmaceutical compositions, dosage forms and methods of administration are set forth.