[2-Amino-3-(2-fluorophenyl)propyl] carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-Amino-3-(2-fluorophenyl)propyl] carbamate
• 化学式: C₁₀H₁₃FN₂O₂
• 分子量: 212.22
• InChiKey: FHSGDONTMBTMCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  78.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• AMINOCARBONYLCARBAMATE COMPOUNDS
  申请人：SK BIOPHARMACEUTICALS CO., LTD.

  公开号：US20150246874A1

  公开（公告）日：2015-09-03

  The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R 1 and R 2 are independently H— or alkyl; R 3 is H—, alkyl or aralkyl; and R 4 is H— or aryl.

  本公开提供一种由化学式（I）表示的化合物和一种药用可接受的盐，作为多巴胺再摄取抑制剂，并提供了使用该化合物的方法：其中X分别是卤素，烷基，烷氧基或硝基；m为0, 1, 2, 3或4；n为1或2；R1和R2分别是H-或烷基；R3是H-，烷基或芳基烷基；R4是H-或芳基。
• Aminocarbonylcarbamate compounds
  申请人：SK BIOPHARMACEUTICALS CO., LTD.

  公开号：US10314808B2

  公开（公告）日：2019-06-11

  The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

  本公开提供了一种由式（I）代表的化合物和一种药学上可接受的盐，它们作为多巴胺再摄取抑制剂是有效的，还提供了一种使用该化合物的方法： 其中 X 独立地为卤代、烷基、烷氧基或硝基；m 为 0、1、2、3 或 4；n 为 1 或 2；R1 和 R2 独立地为 H-或烷基；R3 为 H-、烷基或芳烷基；R4 为 H-或芳基。
• METHODS FOR TREATING DRUG ADDICTION AND IMPROVING ADDICTION-RELATED BEHAVIOR
  申请人：Lee Sung James

  公开号：US20100331332A1

  公开（公告）日：2010-12-30

  The invention is directed to a method of treating addiction to drugs of abuse in a subject, comprising administering a therapeutically effective amount of a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof.
• Aminocarbonylcarbamate Compounds
  申请人：SK BIOPHARMACEUTICALS CO., LTD.

  公开号：US20190247356A1

  公开（公告）日：2019-08-15

  The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R 1 and R 2 are independently H— or alkyl; R 3 is H—, alkyl or aralkyl; and R 4 is H— or aryl.
• US8232315B2
  申请人：——

  公开号：US8232315B2

  公开（公告）日：2012-07-31